SCOPe 2.08: Domain d1oi9a1: 1oi9 A:1-296

Lineage for d1oi9a1 (1oi9 A:1-296)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d1oi9a1: 1oi9 A:1-296 [103946]
   Other proteins in same PDB: d1oi9a2, d1oi9b1, d1oi9b2, d1oi9c2, d1oi9d1, d1oi9d2
   complexed with mg, n20, sgm

Details for d1oi9a1

PDB Entry: 1oi9, 2.1 Å

PDB Description: structure of human thr160-phospho cdk2/cyclin a complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d1oi9a1:

Sequence, based on SEQRES records:

>d1oi9a1 d.144.1.7 (A:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Sequence, based on observed residues (ATOM records):

>d1oi9a1 d.144.1.7 (A:1-296) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirltetegvpstaireisllkelnhp
nivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl

Timeline for d1oi9a1:

• d1oi9a1 first appeared in SCOP 1.69, called d1oi9a_
  
• d1oi9a1 appears in SCOPe 2.07