SCOPe 2.01: Domain d1uu8a_: 1uu8 A:

Lineage for d1uu8a_ (1uu8 A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (17 PDB entries)
   Uniprot O15530 75-363

8. Domain d1uu8a_: 1uu8 A: [100001]
   complexed with bi1, gol, so4

Details for d1uu8a_

PDB Entry: 1uu8, 2.5 Å

PDB Description: structure of human pdk1 kinase domain in complex with bim-1

PDB Compounds: (A:) 3-phosphoinositide dependent protein kinase-1

SCOPe Domain Sequences for d1uu8a_:

Sequence, based on SEQRES records:

>d1uu8a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
pqprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrer
dvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivs
aleylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvsp
ellteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkard
lvekllvldatkrlgceemegygplkahpffesvtwenlhqqtppkl

Sequence, based on observed residues (ATOM records):

>d1uu8a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
pqprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrer
dvmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivs
aleylhgkgiihrdlkpenillnedmhiqitdfgtakvlsnsfvgtaqyvspellteksa
ckssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvl
datkrlgceemegygplkahpffesvtwenlhqqtppkl

Timeline for d1uu8a_:

• d1uu8a_ first appeared in SCOP 1.67
  
• d1uu8a_ appears in SCOP 1.75
  
• d1uu8a_ appears in SCOPe 2.02
  
• d1uu8a_ appears in the current release, SCOPe 2.08