Lineage for d2fr1a2 (2fr1 A:1448-1656)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2841004Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2841005Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2841375Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

    has additional subdomain(s) that are not in the common domain
  6. 2842423Protein Erythromycin synthase, eryAI, 1st ketoreductase module, N-terminal domain [418934] (1 species)
    protein contains tandem repeat of two SDR-like modules resembling a dimer commonly found in the family; only the second module retains the coenzyme-binding site
  7. 2842424Species Saccharopolyspora erythraea [TaxId:1836] [419372] (4 PDB entries)
    Uniprot Q5UNP6
  8. 2842425Domain d2fr1a2: 2fr1 A:1448-1656 [133962]
    Other proteins in same PDB: d2fr1a1
    automated match to d2fr0a2
    complexed with ndp

Details for d2fr1a2

PDB Entry: 2fr1 (more details), 1.79 Å

PDB Description: The first ketoreductase of the erythromycin synthase (crystal form 2)
PDB Compounds: (A:) Erythromycin synthase, EryAI

SCOPe Domain Sequences for d2fr1a2:

Sequence; same for both SEQRES and ATOM records: (download)

>d2fr1a2 c.2.1.2 (A:1448-1656) Erythromycin synthase, eryAI, 1st ketoreductase module, N-terminal domain {Saccharopolyspora erythraea [TaxId: 1836]}
devsalryriewrptgageparldgtwlvakyagtadetstaarealesagarvrelvvd
arcgrdelaerlrsvgevagvlsllavdeaepeeaplalasladtlslvqamvsaelgcp
lwtvtesavatgpfervrnaahgalwgvgrvialenpavwgglvdvpagsvaelarhlaa
vvsggagedqlalradgvygrrwvraaap

SCOPe Domain Coordinates for d2fr1a2:

Click to download the PDB-style file with coordinates for d2fr1a2.
(The format of our PDB-style files is described here.)

Timeline for d2fr1a2:

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Domains from same chain:
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d2fr1a1