Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) |
Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins) also known as short-chain dehydrogenases and SDR family parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 has additional subdomain(s) that are not in the common domain |
Protein Erythromycin synthase, eryAI, 1st ketoreductase module, N-terminal domain [418934] (1 species) protein contains tandem repeat of two SDR-like modules resembling a dimer commonly found in the family; only the second module retains the coenzyme-binding site |
Species Saccharopolyspora erythraea [TaxId:1836] [419372] (4 PDB entries) Uniprot Q5UNP6 |
Domain d2fr1a2: 2fr1 A:1448-1656 [133962] Other proteins in same PDB: d2fr1a1 automated match to d2fr0a2 complexed with ndp |
PDB Entry: 2fr1 (more details), 1.79 Å
SCOPe Domain Sequences for d2fr1a2:
Sequence; same for both SEQRES and ATOM records: (download)
>d2fr1a2 c.2.1.2 (A:1448-1656) Erythromycin synthase, eryAI, 1st ketoreductase module, N-terminal domain {Saccharopolyspora erythraea [TaxId: 1836]} devsalryriewrptgageparldgtwlvakyagtadetstaarealesagarvrelvvd arcgrdelaerlrsvgevagvlsllavdeaepeeaplalasladtlslvqamvsaelgcp lwtvtesavatgpfervrnaahgalwgvgrvialenpavwgglvdvpagsvaelarhlaa vvsggagedqlalradgvygrrwvraaap
Timeline for d2fr1a2: