PDB entry 7jh2
View 7jh2 on RCSB PDB site
Description: crystal structure of rar-related orphan receptor c in complex with a potent, selective and orally bioavailable ror-gamma-t inverse agonist
Class: transcription/agonist
Keywords: RORGT, NUCLEAR HORMONE RECEPTOR, LIGAND-BINDING DOMAIN, INVERSE AGONIST, TRANSCRIPTION-AGONIST complex
Deposited on
2020-07-20, released
2020-08-12
The last revision prior to the SCOPe 2.07 freeze date was dated
2020-08-19, with a file datestamp of
2020-08-14.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.34
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Nuclear receptor ROR-gamma
Species: Homo sapiens [TaxId:9606]
Gene: RORC, NR1F3, RORG, RZRG
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Nuclear receptor ROR-gamma
Species: Homo sapiens [TaxId:9606]
Gene: RORC, NR1F3, RORG, RZRG
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d7jh2b_ - Heterogens: VBG, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>7jh2B (B:)
mgsshhhhhhssglvprgshmaslteiehlvqsvcksyretcqlrledllrqrsnifsre
evtgyqrksmwemwercahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlv
rmcraynadnrtvffegkyggmelfralgcselissifdfshslsalhfsedeialytal
vlinahrpglqekrkveqlqynlelafhhhlckthrqsilaklppkgklrslcsqhverl
qifqhlhpivvqaafpplykelfst
Sequence, based on observed residues (ATOM records): (download)
>7jh2B (B:)
aslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhl
teaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkygg
melfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqy
nlelafhhhlckthrqsilaklppkgklrslcsqhverlqifqhlh