PDB entry 7ak5

View 7ak5 on RCSB PDB site
Description: Cryo-EM structure of respiratory complex I in the deactive state from Mus musculus at 3.2 A
Class: oxidoreductase
Keywords: deactive complex I, OXIDOREDUCTASE
Deposited on 2020-09-29, released 2021-02-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-02-10, with a file datestamp of 2021-02-05.
Experiment type: EM
Resolution: 3.17 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: NADH-ubiquinone oxidoreductase chain 3
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03899 (0-114)
• Chain 'B':
  Compound: nadh dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9DC70 (Start-223)
• Chain 'C':
  Compound: nadh dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9DCT2
• Chain 'D':
  Compound: nadh dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q91WD5 (Start-462)
• Chain 'E':
  Compound: nadh dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9D6J6 (Start-244)
• Chain 'F':
  Compound: nadh dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q91YT0
  Domains in SCOPe 2.07: d7ak5f1, d7ak5f2, d7ak5f3
• Chain 'G':
  Compound: nadh-ubiquinone oxidoreductase 75 kda subunit, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q91VD9 (Start-714)
• Chain 'H':
  Compound: NADH-ubiquinone oxidoreductase chain 1
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03888 (0-317)
• Chain 'I':
  Compound: nadh dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q8K3J1 (Start-211)
• Chain 'J':
  Compound: NADH-ubiquinone oxidoreductase chain 6
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03925 (0-End)
• Chain 'K':
  Compound: NADH-ubiquinone oxidoreductase chain 4L
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03903 (0-97)
• Chain 'L':
  Compound: NADH-ubiquinone oxidoreductase chain 5
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03921 (0-End)
• Chain 'M':
  Compound: NADH-ubiquinone oxidoreductase chain 4
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03911 (0-458)
• Chain 'N':
  Compound: NADH-ubiquinone oxidoreductase chain 2
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03893 (0-End)
• Chain 'O':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99LC3 (Start-354)
• Chain 'P':
  Compound: nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9DC69 (Start-376)
• Chain 'Q':
  Compound: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CXZ1 (Start-174)
• Chain 'R':
  Compound: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P52503 (Start-113)
• Chain 'S':
  Compound: nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQ75
• Chain 'T':
  Compound: acyl carrier protein, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CR21
  Domains in SCOPe 2.07: d7ak5t_
• Chain 'U':
  Compound: acyl carrier protein, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CR21 (Start-155)
  Domains in SCOPe 2.07: d7ak5u_
• Chain 'V':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CPP6 (Start-115)
• Chain 'W':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQZ5 (Start-130)
• Chain 'X':
  Compound: nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9DCJ5 (Start-171)
• Chain 'Y':
  Compound: mcg5603
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot G5E814 (Start-142)
• Chain 'Z':
  Compound: nadh dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9ERS2 (Start-143)
• Chain 'a':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot O35683 (0-67)
• Chain 'b':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQ91 (0-82)
• Chain 'c':
  Compound: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQY9
• Chain 'd':
  Compound: NADH dehydrogenase [ubiquinone] 1 subunit C2
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQ54 (0-End)
• Chain 'e':
  Compound: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99LY9
• Chain 'f':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P0DN34
• Chain 'g':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot O09111
• Chain 'h':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQH3 (Start-188)
• Chain 'i':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q3UIU2 (0-End)
• Chain 'j':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CPU2
• Chain 'k':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQZ6
• Chain 'l':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9D6J5 (Start-185)
• Chain 'm':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQC7 (Start-128)
• Chain 'n':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CQJ8
• Chain 'o':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9CR61
• Chain 'p':
  Compound: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9DCS9
• Chain 'q':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q7TMF3
• Chain 'r':
  Compound: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9Z1P6 (0-111)
• Chain 's':
  Compound: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
  Species: Mus musculus [TaxId:10090]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q8BK30
• Heterogens: SF4, PC1, FES, FMN, 3PE, CDL, ATP, NDP, ZN, EHZ

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  Sequence, based on SEQRES records: (download)
  

  >7ak5F (F:)
  mlaarhflgglvpvrvsvrfssgttapkktsfgslkdedriftnlygrhdwrlkgalrrg
  dwyktkeillkgpdwilgemktsglrgrggagfptglkwsfmnkpsdgrpkylvvnadeg
  epgtckdreimrhdphklvegclvggramgaraayiyirgefyneasnlqvaireayeag
  ligknacgsdydfdvfvvrgagayicgeetaliesiegkqgkprlkppfpadvgvfgcpt
  tvanvetvavspticrrggtwfagfgrernsgtklfnisghvnhpctveeemsvplkeli
  ekhaggvtggwdnllavipggsstplipksvcetvlmdfdalvqaqtglgtaavivmdrs
  tdivkaiarliefykhescgqctpcregvdwmnkvmarfvkgdarpaeidslweiskqie
  ghticalgdgaawpvqglirhfrpeledrmqrfaqqhrawqaas
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >7ak5F (F:)
  tsfgslkdedriftnlygrhdwrlkgalrrgdwyktkeillkgpdwilgemktsglrgrg
  gagfptglkwsfmnkpsdgrpkylvvnadegepgtckdreimrhdphklvegclvggram
  garaayiyirgefyneasnlqvaireayeagligknacgsdydfdvfvvrgagayicgee
  taliesiegkqgkprlkppfpadvgvfgcpttvanvetvavspticrrggtwfagfgrer
  nsgtklfnisghvnhpctveeemsvplkeliekhaggvtggwdnllavipggsstplipk
  svcetvlmdfdalvqaqtglgtaavivmdrstdivkaiarliefykhescgqctpcregv
  dwmnkvmarfvkgdarpaeidslweiskqieghticalgdgaawpvqglirhfrpeledr
  mqrfaqqh
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  No sequence available.
  
  
• Chain 'K':
  No sequence available.
  
  
• Chain 'L':
  No sequence available.
  
  
• Chain 'M':
  No sequence available.
  
  
• Chain 'N':
  No sequence available.
  
  
• Chain 'O':
  No sequence available.
  
  
• Chain 'P':
  No sequence available.
  
  
• Chain 'Q':
  No sequence available.
  
  
• Chain 'R':
  No sequence available.
  
  
• Chain 'S':
  No sequence available.
  
  
• Chain 'T':
  Sequence, based on SEQRES records: (download)
  

  >7ak5T (T:)
  masrvlcacvrrlpaafaplprlptlalarplsttlcpegirrrpgalqsalalaqvpgt
  vthlcrqysdappltldgikdrvlyvlklydkidpeklsvnshfmkdlgldsldqveiim
  amedefgfeipdidaeklmcpqeivdyiadkkdvye
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >7ak5T (T:)
  gikdrvlyvlklydkidpeklsvnshfmkdlgldsldqveiimamedefgfeipdidaek
  lmcpqeivdyiad
  

  
  
• Chain 'U':
  Sequence, based on SEQRES records: (download)
  

  >7ak5U (U:)
  masrvlcacvrrlpaafaplprlptlalarplsttlcpegirrrpgalqsalalaqvpgt
  vthlcrqysdappltldgikdrvlyvlklydkidpeklsvnshfmkdlgldsldqveiim
  amedefgfeipdidaeklmcpqeivdyiadkkdvye
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >7ak5U (U:)
  sdappltldgikdrvlyvlklydkidpeklsvnshfmkdlgldsldqveiimamedefgf
  eipdidaeklmcpqeivdyiadkkdvye
  

  
  
• Chain 'V':
  No sequence available.
  
  
• Chain 'W':
  No sequence available.
  
  
• Chain 'X':
  No sequence available.
  
  
• Chain 'Y':
  No sequence available.
  
  
• Chain 'Z':
  No sequence available.
  
  
• Chain 'a':
  No sequence available.
  
  
• Chain 'b':
  No sequence available.
  
  
• Chain 'c':
  No sequence available.
  
  
• Chain 'd':
  No sequence available.
  
  
• Chain 'e':
  No sequence available.
  
  
• Chain 'f':
  No sequence available.
  
  
• Chain 'g':
  No sequence available.
  
  
• Chain 'h':
  No sequence available.
  
  
• Chain 'i':
  No sequence available.
  
  
• Chain 'j':
  No sequence available.
  
  
• Chain 'k':
  No sequence available.
  
  
• Chain 'l':
  No sequence available.
  
  
• Chain 'm':
  No sequence available.
  
  
• Chain 'n':
  No sequence available.
  
  
• Chain 'o':
  No sequence available.
  
  
• Chain 'p':
  No sequence available.
  
  
• Chain 'q':
  No sequence available.
  
  
• Chain 'r':
  No sequence available.
  
  
• Chain 's':
  No sequence available.