PDB entry 6yd7

View 6yd7 on RCSB PDB site
Description: X-ray structure of furin in complex with the canavanine-based inhibitor 4-guanidinomethyl-phenylacetyl-Arg-Tle-Canavanine-Amba
Class: hydrolase
Keywords: Protease, Inhibitor, Complex, Canavanine, HYDROLASE
Deposited on 2020-03-20, released 2021-02-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-02-17, with a file datestamp of 2021-02-12.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FURIN, FUR, PACE, PCSK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09958 (Start-466)
      • expression tag (467-473)
    Domains in SCOPe 2.07: d6yd7a1, d6yd7a2, d6yd7a3
  • Heterogens: CA, NA, CL, PO4, DMS, 2UE, ARG, TBG, ON8, 00S, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6yd7A (A:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6yd7A (A:)
vyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ndwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevr
ktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgf
ndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvpr