PDB entry 6mxx

View 6mxx on RCSB PDB site
Description: Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991
Class: protein binding
Keywords: 53BP1, Tandem Tudor domains, Small molecule inhibitor, DNA damage response, Class switch recombination, Protein Binding
Deposited on 2018-10-31, released 2019-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxa1, d6mxxa2
  • Chain 'B':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxb1, d6mxxb2
  • Chain 'C':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12888 (3-End)
      • expression tag (1-2)
    Domains in SCOPe 2.08: d6mxxc1, d6mxxc2, d6mxxc3
  • Chain 'D':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxd1, d6mxxd2
  • Chain 'E':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxe1, d6mxxe2
  • Chain 'F':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxf1, d6mxxf2
  • Chain 'G':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxg1, d6mxxg2
  • Chain 'H':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxh1, d6mxxh2
  • Chain 'I':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6mxxi1, d6mxxi2
  • Chain 'J':
    Compound: TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12888 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d6mxxj1, d6mxxj2, d6mxxj3
  • Heterogens: PO4, K6P, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6mxxA (A:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxA (A:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6mxxB (B:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxB (B:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6mxxC (C:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxC (C:)
hmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipld
tevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyg
l

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6mxxD (D:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxD (D:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6mxxE (E:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxE (E:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6mxxF (F:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxF (F:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqyglg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6mxxG (G:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxG (G:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6mxxH (H:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxH (H:)
nsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldte
vtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6mxxI (I:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxI (I:)
sfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldtev
talsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6mxxJ (J:)
ghmnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipl
dtevtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqy
glg

    Sequence, based on observed residues (ATOM records): (download) 
    >6mxxJ (J:)
mnsfvglrvvakwssngyfysgkitrdvgagkykllfddgyecdvlgkdillcdpipldt
evtalsedeyfsagvvkghrkesgelyysiekegqrkwykrmavilsleqgnrlreqygl