PDB entry 6lz9
View 6lz9 on RCSB PDB site
Description: t8E4 antibody Fab complexed with the active form of HGF
Class: immune system
Keywords: antibody, HGF, hepatocyte growth factor, active form, IMMUNE SYSTEM
Deposited on
2020-02-18, released
2020-03-11
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-03-11, with a file datestamp of
2020-03-06.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: hepatocyte growth factor
Species: Homo sapiens [TaxId:9606]
Gene: HGF, HPTA
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: hepatocyte growth factor
Species: Homo sapiens [TaxId:9606]
Gene: HGF, HPTA
Database cross-references and differences (RAF-indexed):
- Uniprot P14210 (0-End)
- engineered mutation (66)
- engineered mutation (71)
- engineered mutation (158)
Domains in SCOPe 2.08: d6lz9b_ - Chain 'H':
Compound: Heavy chain of t8E4 Fab fragment
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6lz9h_ - Chain 'L':
Compound: Light chain of t8E4 Fab fragment
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6lz9l1, d6lz9l2 - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6lz9B (B:)
vvngiptrtnigwmvslryrnkhicggslikeswvltarqcfpsrdlkdyeawlgihdvh
grgdekskqvlqvsqlvygpegsdlvlmklarpavlddfvstidlpnygctipektscsv
ygwgytglinydgllrvahlyimgnekcsqhhrgkvtlqeseicagaekigsgpcegdyg
gplvceqhkmrmvlgvivpgrgcaipnrpgifvrvayyakwihkiiltykvpqsrlenly
fq
Sequence, based on observed residues (ATOM records): (download)
>6lz9B (B:)
vvngiptrtnigwmvslryrnkhicggslikeswvltarqcfpsrdlkdyeawlgihdvh
grgdekskqvlqvsqlvygpegsdlvlmklarpavlddfvstidlpnygctipektscsv
ygwgytglinydgllrvahlyimgnekcsqlqeseicagaigsgpcegdyggplvceqhk
mrmvlgvivpgrgcaipnrpgifvrvayyakwihkiiltykvp
- Chain 'H':
Sequence, based on SEQRES records: (download)
>6lz9H (H:)
evqlkesgpdlvqpsqtlsltctvsgfsltgygvhwvrqppgkglewvgtlgwndkkyyn
salksrlsisrdtsknqvflklssletedtamyyctrdggllfayyamdywgqgtsvtvs
sakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqs
dlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc
Sequence, based on observed residues (ATOM records): (download)
>6lz9H (H:)
evqlkesgpdlvqpsqtlsltctvsgfsltgygvhwvrqppgkglewvgtlgwndkkyyn
salksrlsisrdtsknqvflklssletedtamyyctrdggllfayyamdywgqgtsvtvs
sakttppsvyplapgnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpsstwpsetvtcnvahpasstkvdkkivprdc
- Chain 'L':
Sequence, based on SEQRES records: (download)
>6lz9L (L:)
diqmtqttsslsaslgdrvtfscrasqdisnylnwyqqkpdgtvkllifytsrlhsgvps
rfsgsgsgtdysltianleqedfatyfcqqdskhpftfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec
Sequence, based on observed residues (ATOM records): (download)
>6lz9L (L:)
diqmtqttsslsaslgdrvtfscrasqdisnylnwyqqkpdgtvkllifytsrlhsgvps
rfsgsgsgtdysltianleqedfatyfcqqdskhpftfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrne