PDB entry 6lz9

View 6lz9 on RCSB PDB site
Description: t8E4 antibody Fab complexed with the active form of HGF
Class: immune system
Keywords: antibody, HGF, hepatocyte growth factor, active form, IMMUNE SYSTEM
Deposited on 2020-02-18, released 2020-03-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hepatocyte growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: HGF, HPTA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: hepatocyte growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: HGF, HPTA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210 (0-End)
      • engineered mutation (66)
      • engineered mutation (71)
      • engineered mutation (158)
    Domains in SCOPe 2.08: d6lz9b_
  • Chain 'H':
    Compound: Heavy chain of t8E4 Fab fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6LZ9 (0-222)
    Domains in SCOPe 2.08: d6lz9h_
  • Chain 'L':
    Compound: Light chain of t8E4 Fab fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6LZ9 (0-End)
    Domains in SCOPe 2.08: d6lz9l1, d6lz9l2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6lz9B (B:)
vvngiptrtnigwmvslryrnkhicggslikeswvltarqcfpsrdlkdyeawlgihdvh
grgdekskqvlqvsqlvygpegsdlvlmklarpavlddfvstidlpnygctipektscsv
ygwgytglinydgllrvahlyimgnekcsqhhrgkvtlqeseicagaekigsgpcegdyg
gplvceqhkmrmvlgvivpgrgcaipnrpgifvrvayyakwihkiiltykvpqsrlenly
fq

    Sequence, based on observed residues (ATOM records): (download) 
    >6lz9B (B:)
vvngiptrtnigwmvslryrnkhicggslikeswvltarqcfpsrdlkdyeawlgihdvh
grgdekskqvlqvsqlvygpegsdlvlmklarpavlddfvstidlpnygctipektscsv
ygwgytglinydgllrvahlyimgnekcsqlqeseicagaigsgpcegdyggplvceqhk
mrmvlgvivpgrgcaipnrpgifvrvayyakwihkiiltykvp

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6lz9H (H:)
evqlkesgpdlvqpsqtlsltctvsgfsltgygvhwvrqppgkglewvgtlgwndkkyyn
salksrlsisrdtsknqvflklssletedtamyyctrdggllfayyamdywgqgtsvtvs
sakttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqs
dlytlsssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

    Sequence, based on observed residues (ATOM records): (download) 
    >6lz9H (H:)
evqlkesgpdlvqpsqtlsltctvsgfsltgygvhwvrqppgkglewvgtlgwndkkyyn
salksrlsisrdtsknqvflklssletedtamyyctrdggllfayyamdywgqgtsvtvs
sakttppsvyplapgnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpsstwpsetvtcnvahpasstkvdkkivprdc

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6lz9L (L:)
diqmtqttsslsaslgdrvtfscrasqdisnylnwyqqkpdgtvkllifytsrlhsgvps
rfsgsgsgtdysltianleqedfatyfcqqdskhpftfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6lz9L (L:)
diqmtqttsslsaslgdrvtfscrasqdisnylnwyqqkpdgtvkllifytsrlhsgvps
rfsgsgsgtdysltianleqedfatyfcqqdskhpftfgsgtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrne