PDB entry 6j14

View 6j14 on RCSB PDB site
Description: Complex structure of GY-14 and PD-1
Class: immune system
Keywords: tumor immunotherapy, complex structure, FG loop, IMMUNE SYSTEM
Deposited on 2018-12-27, released 2019-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-06, with a file datestamp of 2019-11-01.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GY-14 heavy chain V fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6J14
    Domains in SCOPe 2.08: d6j14a1, d6j14a2
  • Chain 'B':
    Compound: GY-14 light chain V fragment
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6J14 (0-111)
    Domains in SCOPe 2.08: d6j14b_
  • Chain 'G':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6j14g_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6j14A (A:)
qvqlqqsgaelvrpgasvklsckalgdtftdyeihwvkqtpvhglewigvihpgsggtvy
nqkfkgkatltadkysstaymelssltsedsavyyctregmntdwyfdvwgagttvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >6j14A (A:)
qlqqsgaelvrpgasvklsckalgdyeihwvkqtpvhglewigvihpgsggtvynqkfkg
katltadkysstaymelssltsedsavyyctregmntdwyfdvwgagttvtvs

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6j14B (B:)
dilmtqdelslpvslgdqasiscrssqtivhtngntylewylqkpgqspklliykvsnrf
sgvpdrfsgsgsgtyftlkisrleaedlgvyycfqgshvpytfgggtklemk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6j14G (G:)
npptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdklaafpedrsqpgqd
crfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslraelrvter

    Sequence, based on observed residues (ATOM records): (download) 
    >6j14G (G:)
npptfspallvvtegdnatftcsfvlnwyrmspsnqtdklaafpdcrfrvtqlpngrdfh
msvvrarrndsgtylcgaislapkaqikeslraelrvter