PDB entry 6ea4

View 6ea4 on RCSB PDB site
Description: ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor
Class: hydrolase/inhibitor
Keywords: Inhibitor, Immunity, Aminopeptidase, HYDROLASE, HYDROLASE-INHIBITOR complex
Deposited on 2018-08-02, released 2019-12-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • variant (391)
      • expression tag (960-962)
    Domains in SCOPe 2.07: d6ea4a1, d6ea4a2, d6ea4a3, d6ea4a4, d6ea4a5
  • Chain 'B':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • variant (391)
      • expression tag (960)
    Domains in SCOPe 2.07: d6ea4b1, d6ea4b2, d6ea4b3, d6ea4b4, d6ea4b5
  • Heterogens: ZN, MES, J2G, LYS, NAG, BMA, MAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ea4A (A:)
mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ea4A (A:)
fpvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhs
kdleitnatlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqakl
gdgfegfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhia
lsnmpkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdk
rnqthyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfd
pktssasdklwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelq
fddyflnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgee
kfqkgiiqylkkfsyrnaknddlwsslsnenaevkemmttwtlqkgipllvvkqdgcslr
lqqerflqgvfqedpewralqerylwhipltystsssnvihrhilksktdtldlpektsw
vkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldka
ldmtyylqhetsspalleglsylesfyhmmdrrnisdisenlkryllqyfkpvidrqsws
dkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmessgklniptdvlkivysvgaq
ttagwnylleqyelsmssaeqnkilyalstskhqekllklielgmegkviktqnlaallh
aiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisgttahfsskdklqevklffes
leaqgshldifqtvletitknikwleknlptlrtwlmvntrhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ea4B (B:)
mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ea4B (B:)
pvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhsk
dleitnatlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklg
dgfegfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhial
snmpkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkr
nqthyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdp
ktssasdklwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqf
ddyflnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeek
fqkgiiqylkkfsyrnaknddlwsslsnvkemmttwtlqkgipllvvkqdgcslrlqqer
flqgvfqedpewralqerylwhipltystsssnvihrhilksktdtldlpektswvkfnv
dsngyyivhyeghgwdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldmty
ylqhetsspalleglsylesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkgsv
wdrmlrsallklacdlnhapciqkaaelfsqwmessgklniptdvlkivysvgaqttagw
nylleqyelsmssaeqnkilyalstskhqekllklielgmegkviktqnlaallhaiarr
pkgqqlawdfvrenwthllkkfdlgsydirmiisgttahfsskdklqevklffesleaqg
shldifqtvletitknikwleknlptlrtwlmvntr