PDB entry 5w12

View 5w12 on RCSB PDB site
Description: ADC-7 in complex with boronic acid transition state inhibitor EC04
Class: hydrolase/hydrolase inhibitor
Keywords: inhibitor, Beta-lactamase, BATSI, EC04, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2017-06-01, released 2017-11-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-12-20, with a file datestamp of 2017-12-15.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase
    Species: ACINETOBACTER BAUMANNII [TaxId:470]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5w12a_
  • Chain 'B':
    Compound: Beta-lactamase
    Species: ACINETOBACTER BAUMANNII [TaxId:470]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5w12b_
  • Chain 'C':
    Compound: Beta-lactamase
    Species: ACINETOBACTER BAUMANNII [TaxId:470]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5w12c_
  • Chain 'D':
    Compound: Beta-lactamase
    Species: ACINETOBACTER BAUMANNII [TaxId:470]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5w12d_
  • Heterogens: 9TG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5w12A (A:)
mdntpkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsnt
ifelgsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnla
lqfpdevqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlekti
fpalglkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihan
lnpqkyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkv
taiskepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaik
k

    Sequence, based on observed residues (ATOM records): (download) 
    >5w12A (A:)
qeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsntifelgsv
sklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnlalqfpdev
qtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlektifpalglk
hsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihanlnpqkyp
tdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkvtaiskep
svkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5w12B (B:)
mdntpkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsnt
ifelgsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnla
lqfpdevqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlekti
fpalglkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihan
lnpqkyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkv
taiskepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaik
k

    Sequence, based on observed residues (ATOM records): (download) 
    >5w12B (B:)
tpkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsntife
lgsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnlalqf
pdevqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlektifpa
lglkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihanlnp
qkyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkvtai
skepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaikk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5w12C (C:)
mdntpkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsnt
ifelgsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnla
lqfpdevqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlekti
fpalglkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihan
lnpqkyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkv
taiskepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaik
k

    Sequence, based on observed residues (ATOM records): (download) 
    >5w12C (C:)
pkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsntifel
gsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnlalqfp
devqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlektifpal
glkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihanlnpq
kyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkvtais
kepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaikk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5w12D (D:)
mdntpkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsnt
ifelgsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnla
lqfpdevqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlekti
fpalglkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihan
lnpqkyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkv
taiskepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnaik
k

    Sequence, based on observed residues (ATOM records): (download) 
    >5w12D (D:)
pkdqeikklvdqnfkpllekydvpgmavgviqnnkkyemyyglqsvqdkkavnsntifel
gsvsklftataggyaknkgkisfddtpgkywkelkntpidqvnllqlatytsgnlalqfp
devqtdqqvltffkdwkpknpigeyrqysnpsiglfgkvvalsmnkpfdqvlektifpal
glkhsyvnvpktqmqnyafgynqenqpirvnpgpldapaygvkstlpdmlsfihanlnpq
kyptdiqrainethqgryqvntmyqalgweefsypatlqtlldsnseqivmkpnkvtais
kepsvkmyhktgstsgfgtyvvfipkeniglvmltnkripneerikaayvvlnai