PDB entry 5uax

View 5uax on RCSB PDB site
Description: Structure of apo human PYCR-1 crystallized in space group C2
Class: oxidoreductase
Keywords: amino-acid biosynthesis, oxidoreductase, proline biosynthesis
Deposited on 2016-12-20, released 2017-03-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (8-277)
      • expression tag (0-7)
    Domains in SCOPe 2.07: d5uaxa1, d5uaxa2, d5uaxa3
  • Chain 'B':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (8-277)
      • expression tag (5-7)
    Domains in SCOPe 2.07: d5uaxb1, d5uaxb2, d5uaxb3
  • Chain 'C':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (8-277)
      • expression tag (2-7)
    Domains in SCOPe 2.07: d5uaxc1, d5uaxc2, d5uaxc3
  • Chain 'D':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32322 (8-End)
      • expression tag (7)
    Domains in SCOPe 2.07: d5uaxd1, d5uaxd2, d5uaxd3
  • Chain 'E':
    Compound: Pyrroline-5-carboxylate reductase 1, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PYCR1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5uaxe1, d5uaxe2
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5uaxA (A:)
tenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkl
tphnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafr
paprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtg
lsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvs
spggatihalhvlesggfrsllinaveascirtrelqs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uaxB (B:)
tenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkl
tphnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafr
paprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtg
lsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvs
spggatihalhvlesggfrsllinaveascirtrelqs

    Sequence, based on observed residues (ATOM records): (download) 
    >5uaxB (B:)
fqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnk
etvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprv
ircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsg
payaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspgga
tihalhvlesggfrsllinaveascirtrelqs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5uaxC (C:)
tenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkl
tphnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafr
paprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtg
lsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvs
spggatihalhvlesggfrsllinaveascirtrelqs

    Sequence, based on observed residues (ATOM records): (download) 
    >5uaxC (C:)
nlyfqsmsvgfigagqlafalakgftaagvlaahkimassmdlatvsalrkmgvkltphn
ketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpapr
vircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgs
gpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspgg
atihalhvlesggfrsllinaveascirtrelqs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5uaxD (D:)
tenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkl
tphnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafr
paprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtg
lsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvs
spggatihalhvlesggfrsllinaveascirtrelqs

    Sequence, based on observed residues (ATOM records): (download) 
    >5uaxD (D:)
smsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkltphnket
vqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafrpaprvir
cmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpa
yaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggati
halhvlesggfrsllinaveascirtrelq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5uaxE (E:)
tenlyfqsmsvgfigagqlafalakgftaagvlaahkimasspdmdlatvsalrkmgvkl
tphnketvqhsdvlflavkphiipfildeigadiedrhivvscaagvtissiekklsafr
paprvircmtntpvvvregatvyatgthaqvedgrlmeqllssvgfcteveedlidavtg
lsgsgpayaftaldaladggvkmglprrlavrlgaqallgaakmllhseqhpgqlkdnvs
spggatihalhvlesggfrsllinaveascirtrelqs

    Sequence, based on observed residues (ATOM records): (download) 
    >5uaxE (E:)
msvgfigagqlafalakgftaagvlaahkimassvkltphnketvqhsdvlflavkphii
pfildeigadiedrhivvscaagvtissiekklsafrpaprvircmtntpvvvregatvy
atgthaqvedgrlmeqllssvgfcteveedlidavtglsgsgpayaftaldaladggvkm
glprrlavrlgaqallgaakmllhseqhpgqlkdnvsspggatihalhvlesggfrslli
naveascirtrelqs