PDB entry 5mkr

View 5mkr on RCSB PDB site
Description: HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation
Class: chaperone
Keywords: Irreversible Inhibitor, Chaperone, Lysine modification
Deposited on 2016-12-05, released 2017-03-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-03-01, with a file datestamp of 2017-02-24.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: heat shock 70 kda protein 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: HSPA1A, HSPA1, HSX70
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DMV8 (5-384)
      • expression tag (385-390)
    Domains in SCOPe 2.06: d5mkra1, d5mkra2, d5mkra3
  • Heterogens: TI8, FLC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5mkrA (A:)
gplgsmakaaaigidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaa
knqvalnpqntvfdakrligrkfgdpvvqsdmkhwpfqvindgdkpkvqvsykgetkafy
peeissmvltkmkeiaeaylgypvtnavitvpayfndsqrqatkdagviaglnvlriine
ptaaaiaygldrtgkgernvlifdlgggtfdvsiltiddgifevkatagdthlggedfdn
rlvnhfveefkrkhkkdisqnkravrrlrtacerakrtlssstqasleidslfegidfyt
sitrarfeelcsdlfrstlepvekalrdakldkaqihdlvlvggstripkvqkllqdffn
grdlnksinpdeavaygaavqaailikstraaas

    Sequence, based on observed residues (ATOM records): (download) 
    >5mkrA (A:)
makaaaigidlgttyscvgvfqhgkveiiandqgnrttpsyvaftdterligdaaknqva
lnpqntvfdakrligrkfgdpvvqsdmkhwpfqvindgdkpkvqvsykgetkafypeeis
smvltkmkeiaeaylgypvtnavitvpayfndsqrqatkdagviaglnvlriineptaaa
iaygldrtggernvlifdlgggtfdvsiltiddgifevkatagdthlggedfdnrlvnhf
veefkrkhkkdisqnkravrrlrtacerakrtlssstqasleidslfegidfytsitrar
feelcsdlfrstlepvekalrdakldkaqihdlvlvggstripkvqkllqdffngrdlnk
sinpdeavaygaavqaailikstra