PDB entry 5low

View 5low on RCSB PDB site
Description: Structure of the Ca2+-bound Rabphilin 3A C2B domain SNAP25 complex (P21 space group)
Class: exocytosis
Keywords: membrane fusion, calcium, C2 domain, exocytosis
Deposited on 2016-08-10, released 2017-06-21
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-06-21, with a file datestamp of 2017-06-16.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: rabphilin-3a
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rph3a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowa_
  • Chain 'B':
    Compound: rabphilin-3a
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rph3a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowb_
  • Chain 'C':
    Compound: rabphilin-3a
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rph3a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowc_
  • Chain 'D':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60881 (19-End)
      • expression tag (17-18)
    Domains in SCOPe 2.06: d5lowd1, d5lowd2
  • Chain 'E':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowe_
  • Chain 'F':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowf_
  • Chain 'G':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60881 (19-End)
      • expression tag (18)
    Domains in SCOPe 2.06: d5lowg1, d5lowg2
  • Chain 'H':
    Compound: rabphilin-3a
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rph3a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowh_
  • Chain 'I':
    Compound: rabphilin-3a
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rph3a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowi_
  • Chain 'J':
    Compound: rabphilin-3a
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Rph3a
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowj_
  • Chain 'K':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60881 (19-End)
      • expression tag (15-18)
    Domains in SCOPe 2.06: d5lowk1, d5lowk2
  • Chain 'L':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowl_
  • Chain 'M':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5lowm_
  • Chain 'N':
    Compound: synaptosomal-associated protein 25
    Species: Rattus norvegicus [TaxId:10116]
    Gene: SNAP25, SNAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60881 (19-End)
      • expression tag (17-18)
    Domains in SCOPe 2.06: d5lown1, d5lown2
  • Heterogens: GOL, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5lowA (A:)
hmasmtggqqmgrgsdfgdieergkilvslmystqqgglivgiircvhlaamdangysdp
fvklwlkpdmgkkakhktqikkktlnpefneeffydikhsdlakksldisvwdydigksn
dyiggcqlgisakgerlkhwyeclknkdkkierwhqlqnenh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowA (A:)
dieergkilvslmystqqgglivgiircvhlaamdangysdpfvklwlkpdmgkkakhkt
qikkktlnpefneeffydikhsdlakksldisvwdydigksndyiggcqlgisakgerlk
hwyeclknkdkkierwhqlqne

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5lowB (B:)
hmasmtggqqmgrgsdfgdieergkilvslmystqqgglivgiircvhlaamdangysdp
fvklwlkpdmgkkakhktqikkktlnpefneeffydikhsdlakksldisvwdydigksn
dyiggcqlgisakgerlkhwyeclknkdkkierwhqlqnenh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowB (B:)
dieergkilvslmystqqgglivgiircvhlaamdangysdpfvklwlkpdmgkkakhkt
qikkktlnpefneeffydikhsdlakksldisvwdydigksndyiggcqlgisakgerlk
hwyeclknkdkkierwhqlqnenh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5lowC (C:)
hmasmtggqqmgrgsdfgdieergkilvslmystqqgglivgiircvhlaamdangysdp
fvklwlkpdmgkkakhktqikkktlnpefneeffydikhsdlakksldisvwdydigksn
dyiggcqlgisakgerlkhwyeclknkdkkierwhqlqnenh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowC (C:)
dieergkilvslmystqqgglivgiircvhlaamdangysdpfvklwlkpdmgkkakhkt
qikkktlnpefneeffydikhsdlakksldisvwdydigksndyiggcqlgisakgerlk
hwyeclknkdkkierwhqlqnenh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5lowD (D:)
gshmasmtggqqmgrgsefmrneleemqrradqladeslestrrmlqlveeskdagirtl
vmldeqgeqldrveegmnhinqdmkeaeknlkdlg

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowD (D:)
efmrneleemqrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldrveegm
nhinqdmk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5lowE (E:)
gshmasmtggqqmgrgsefarenemdenleqvsgiignlrhmaldmgneidtqnrqidri
mekadsnktrideanqratkml

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowE (E:)
renemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5lowF (F:)
gshmasmtggqqmgrgsefmrneleemqrradqladeslestrrmlqlveeskdagirtl
vmldeqgeqldrveegmnhinqdmkeaeknlkdlg

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowF (F:)
qrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldrveegmnhinqdmkea
eknlkdlg

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5lowG (G:)
gshmasmtggqqmgrgsefarenemdenleqvsgiignlrhmaldmgneidtqnrqidri
mekadsnktrideanqratkml

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowG (G:)
farenemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqra

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5lowH (H:)
hmasmtggqqmgrgsdfgdieergkilvslmystqqgglivgiircvhlaamdangysdp
fvklwlkpdmgkkakhktqikkktlnpefneeffydikhsdlakksldisvwdydigksn
dyiggcqlgisakgerlkhwyeclknkdkkierwhqlqnenh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowH (H:)
ergkilvslmystqqgglivgiircvhlaamdangysdpfvklwlkpdmgkkakhktqik
kktlnpefneeffydikhsdlakksldisvwdydigksndyiggcqlgisakgerlkhwy
eclknkdkkierwhqlqnen

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >5lowI (I:)
hmasmtggqqmgrgsdfgdieergkilvslmystqqgglivgiircvhlaamdangysdp
fvklwlkpdmgkkakhktqikkktlnpefneeffydikhsdlakksldisvwdydigksn
dyiggcqlgisakgerlkhwyeclknkdkkierwhqlqnenh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowI (I:)
gdieergkilvslmystqqgglivgiircvhlaamdangysdpfvklwlkpdmgkkakhk
tqikkktlnpefneeffydikhsdlakksldisvwdydigksndyiggcqlgisakgerl
khwyeclknkdkkierwhqlqnenh

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >5lowJ (J:)
hmasmtggqqmgrgsdfgdieergkilvslmystqqgglivgiircvhlaamdangysdp
fvklwlkpdmgkkakhktqikkktlnpefneeffydikhsdlakksldisvwdydigksn
dyiggcqlgisakgerlkhwyeclknkdkkierwhqlqnenh

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowJ (J:)
dieergkilvslmystqqgglivgiircvhlaamdangysdpfvklwlkpdmgkkakhkt
qikkktlnpefneeffydikhsdlakksldisvwdydigksndyiggcqlgisakgerlk
hwyeclknkdkkierwhqlq

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >5lowK (K:)
gshmasmtggqqmgrgsefmrneleemqrradqladeslestrrmlqlveeskdagirtl
vmldeqgeqldrveegmnhinqdmkeaeknlkdlg

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowK (K:)
gsefmrneleemqrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldrvee
gmnhinqdmkea

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5lowL (L:)
gshmasmtggqqmgrgsefarenemdenleqvsgiignlrhmaldmgneidtqnrqidri
mekadsnktrideanqratkml

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowL (L:)
arenemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqrat
kml

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >5lowM (M:)
gshmasmtggqqmgrgsefmrneleemqrradqladeslestrrmlqlveeskdagirtl
vmldeqgeqldrveegmnhinqdmkeaeknlkdlg

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowM (M:)
leemqrradqladeslestrrmlqlveeskdagirtlvmldeqgeqldrveegmnhinqd
mkeaeknlkdlg

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >5lowN (N:)
gshmasmtggqqmgrgsefarenemdenleqvsgiignlrhmaldmgneidtqnrqidri
mekadsnktrideanqratkml

    Sequence, based on observed residues (ATOM records): (download) 
    >5lowN (N:)
efarenemdenleqvsgiignlrhmaldmgneidtqnrqidrimekadsnktrideanqr