PDB entry 5l2w

View 5l2w on RCSB PDB site
Description: The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.
Class: Transferase/Cell Cycle/Inhibitor
Keywords: cyclin-dependent kinase, kinase inhibitor, kinase selectivity, Transferase-Cell Cycle-Inhibitor complex
Deposited on 2016-08-02, released 2016-08-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-08-24, with a file datestamp of 2016-08-18.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.06: d5l2wa1, d5l2wa2
  • Chain 'B':
    Compound: G1/S-specific cyclin-E1
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNE1, CCNE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5l2wb1, d5l2wb2
  • Heterogens: 1QK, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5l2wA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >5l2wA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5l2wB (B:)
mashhhhhhdydgattenlyfqgsiiapsrgsplpvlswanreevwkimlnkektylrdq
hfleqhpllqpkmrailldwlmevcevyklhretfylaqdffdrymatqenvvktllqli
gisslfiaakleeiyppklhqfayvtdgacsgdeiltmelmimkalkwrlspltivswln
vymqvaylndlhevllpqypqqifiqiaelldlcvldvdclefpygilaasalyhfssse
lmqkvsgyqwcdiencvkwmvpfamviretgssklkhfrgvadedahniqthrdsldlld
karakka

    Sequence, based on observed residues (ATOM records): (download) 
    >5l2wB (B:)
splpvlswanreevwkimlnkektylrdqhfleqhpllqpkmrailldwlmevcevyklh
retfylaqdffdrymatqenvvktllqligisslfiaakleeiyppklhqfayvtdgacs
gdeiltmelmimkalkwrlspltivswlnvymqvaylndlhevllpqypqqifiqiaell
dlcvldvdclefpygilaasalyhfssselmqkvsgyqwcdiencvkwmvpfamviretg
ssklkhfrgvadedahniqthrdsldlldk