PDB entry 5ius

View 5ius on RCSB PDB site
Description: Crystal structure of human PD-L1 in complex with high affinity PD-1 mutant
Class: immune system
Keywords: immune checkpoint, tumor surveillance, cancer, receptor, IMMUNE SYSTEM
Deposited on 2016-03-18, released 2016-09-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-06, with a file datestamp of 2017-09-01.
Experiment type: XRAY
Resolution: 2.89 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15116 (Start-124)
      • engineered mutation (42-44)
      • engineered mutation (46)
      • engineered mutation (48)
      • engineered mutation (52)
      • engineered mutation (56)
      • engineered mutation (71)
      • engineered mutation (100)
      • engineered mutation (103)
      • engineered mutation (110)
      • expression tag (125)
    Domains in SCOPe 2.07: d5iusa1, d5iusa2
  • Chain 'B':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15116 (Start-124)
      • engineered mutation (42-44)
      • engineered mutation (46)
      • engineered mutation (48)
      • engineered mutation (52)
      • engineered mutation (56)
      • engineered mutation (71)
      • engineered mutation (100)
      • engineered mutation (103)
      • engineered mutation (110)
      • expression tag (125)
    Domains in SCOPe 2.07: d5iusb1, d5iusb2
  • Chain 'C':
    Compound: Programmed cell death 1 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Programmed cell death 1 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5iusA (A:)
gpgsdspdrpwnpptfspallvvtegdnatftcsfsntsesfhvvwhrespsgqtdtlaa
fpedrsqpgqdarfrvtqlpngrdfhmsvvrarrndsgtyvcgvislapkiqikeslrae
lrvteraaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5iusA (A:)
drpwnpptfspallvvtegdnatftcsfsntsesfhvvwhrespsgqtdtlaafpedrpg
qdarfrvtqlpngrdfhmsvvrarrndsgtyvcgvislapkiqikeslraelrvter

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5iusB (B:)
gpgsdspdrpwnpptfspallvvtegdnatftcsfsntsesfhvvwhrespsgqtdtlaa
fpedrsqpgqdarfrvtqlpngrdfhmsvvrarrndsgtyvcgvislapkiqikeslrae
lrvteraaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5iusB (B:)
rpwnpptfspallvvtegdnatftcsfsntsesfhvvwhrespsgqtdtlaafpedpgqd
arfrvtqlpngrdfhmsvvrarrndsgtyvcgvislapkiqikeslraelrvter

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.