PDB entry 5ibm

View 5ibm on RCSB PDB site
Description: Structure of S502P, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2
Class: hydrolase
Keywords: TYROSINE PHOSPHATASE SHP2 S502P, Tyrosine-protein phosphatase non-receptor type 11, HYDROLASE
Deposited on 2016-02-22, released 2016-04-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-04-13, with a file datestamp of 2016-04-08.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-525)
      • engineered mutation (502)
    Domains in SCOPe 2.06: d5ibma1, d5ibma2, d5ibma3
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN11, PTP2C, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124
      • engineered mutation (502)
    Domains in SCOPe 2.06: d5ibmb1, d5ibmb2, d5ibmb3
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ibmA (A:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >5ibmA (A:)
rrwfhpnitgveaenllltrgvdgsflarpspgdftlsvrrngavthikiqntgdyydly
ggekfatlaelvqyymehqlkeielkyplncadptserwfhghlsgkeaeklltekgkhg
sflvreshpgdfvlsvrtgkskvthvmircqelkydvgggerfdsltdlvehykknpmve
tlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenk
nknryknilpfdhtrvvlhdgdppvsdyinaniimpefkksyiatqgclqntvndfwrmv
fqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklsk
vgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigr
tgtfividilidiirekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymavqhyietl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ibmB (B:)
smtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqnt
gdyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsg
keaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelky
dvgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaet
tdkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpne
pvsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymavqhyietl

    Sequence, based on observed residues (ATOM records): (download) 
    >5ibmB (B:)
srrwfhpnitgveaenllltrgvdgsflarpskspgdftlsvrrngavthikiqntgdyy
dlyggekfatlaelvqyymehqlvielkyplncadptserwfhghlsgkeaeklltekgk
hgsflvresshpgdfvlsvrtgkskvthvmircqelkydvgggerfdsltdlvehykknp
mvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckllysrkegqrq
enknknryknilpfdhtrvvlhdgdppvsdyinaniimpepkksyiatqgclqntvndfw
rmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelk
lskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsag
igrtgtfividilidiirekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymavqhyi
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