PDB entry 5ftj

View 5ftj on RCSB PDB site
Description: Cryo-EM structure of human p97 bound to UPCDC30245 inhibitor
Class: hydrolase
Keywords: hydrolase, single-particle, p97, aaa ATPase
Deposited on 2016-01-14, released 2016-01-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-30, with a file datestamp of 2017-08-25.
Experiment type: EM
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transitional endoplasmic reticulum ATPase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ftja1, d5ftja2, d5ftja3, d5ftja4
  • Chain 'B':
    Compound: Transitional endoplasmic reticulum ATPase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ftjb1, d5ftjb2, d5ftjb3, d5ftjb4
  • Chain 'C':
    Compound: Transitional endoplasmic reticulum ATPase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ftjc1, d5ftjc2, d5ftjc3, d5ftjc4
  • Chain 'D':
    Compound: Transitional endoplasmic reticulum ATPase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ftjd1, d5ftjd2, d5ftjd3, d5ftjd4
  • Chain 'E':
    Compound: Transitional endoplasmic reticulum ATPase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ftje1, d5ftje2, d5ftje3, d5ftje4
  • Chain 'F':
    Compound: Transitional endoplasmic reticulum ATPase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5ftjf1, d5ftjf2, d5ftjf3, d5ftjf4
  • Heterogens: ADP, OJA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ftjA (A:)
masgadskgddlstailkqknrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllk
gkkrreavcivlsddtcsdekirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpid
dtvegitgnlfevylkpyfleayrpirkgdiflvrggmravefkvvetdpspycivapdt
vihcegepikredeeeslnevgyddiggcrkqlaqikemvelplrhpalfkaigvkpprg
illygppgtgktliaravanetgaffflingpeimsklagesesnlrkafeeaeknapai
ifideldaiapkrekthgeverrivsqlltlmdglkqrahvivmaatnrpnsidpalrrf
grfdrevdigipdatgrleilqihtknmkladdvdleqvanethghvgadlaalcseaal
qairkkmdlidledetidaevmnslavtmddfrwalsqsnpsalretvvevpqvtwedig
gledvkrelqelvqypvehpdkflkfgmtpskgvlfygppgcgktllakaianecqanfi
sikgpelltmwfgeseanvreifdkarqaapcvlffdeldsiakarggnigdgggaadrv
inqiltemdgmstkknvfiigatnrpdiidpailrpgrldqliyiplpdeksrvailkan
lrkspvakdvdleflakmtngfsgadlteicqracklairesieseirrererqtnpsam
eveeddpvpeirrdhfeeamrfarrsvsdndirkyemfaqtlqqsrgfgsfrfpsgnqgg
agpsqgsgggtggsvytedndddlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ftjA (A:)
nrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllkgkkrreavcivlsddtcsde
kirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpiddtvegitgnlfevylkpyfl
eayrpirkgdiflvrggmravefkvvetdpspycivapdtvihcegepikredeeeslne
vgyddiggcrkqlaqikemvelplrhpalfkaigvkpprgillygppgtgktliaravan
etgaffflingpeimsklagesesnlrkafeeaeknapaiifideldaiapkrekthgev
errivsqlltlmdglkqrahvivmaatnrpnsidpalrrfgrfdrevdigipdatgrlei
lqihtknmkladdvdleqvanethghvgadlaalcseaalqairkkmdlidledetidae
vmnslavtmddfrwalsqsnpsalretvvevpqvtwediggledvkrelqelvqypvehp
dkflkfgmtpskgvlfygppgcgktllakaianecqanfisikgpelltmwfgeseanvr
eifdkarqaapcvlffdeldsiakarggnigdgggaadrvinqiltemdgmstkknvfii
gatnrpdiidpailrpgrldqliyiplpdeksrvailkanlrkspvakdvdleflakmtn
gfsgadlteicqracklairesieseivpeirrdhfeeamrfarrsvsdndirkyemfaq
tlq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ftjB (B:)
masgadskgddlstailkqknrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllk
gkkrreavcivlsddtcsdekirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpid
dtvegitgnlfevylkpyfleayrpirkgdiflvrggmravefkvvetdpspycivapdt
vihcegepikredeeeslnevgyddiggcrkqlaqikemvelplrhpalfkaigvkpprg
illygppgtgktliaravanetgaffflingpeimsklagesesnlrkafeeaeknapai
ifideldaiapkrekthgeverrivsqlltlmdglkqrahvivmaatnrpnsidpalrrf
grfdrevdigipdatgrleilqihtknmkladdvdleqvanethghvgadlaalcseaal
qairkkmdlidledetidaevmnslavtmddfrwalsqsnpsalretvvevpqvtwedig
gledvkrelqelvqypvehpdkflkfgmtpskgvlfygppgcgktllakaianecqanfi
sikgpelltmwfgeseanvreifdkarqaapcvlffdeldsiakarggnigdgggaadrv
inqiltemdgmstkknvfiigatnrpdiidpailrpgrldqliyiplpdeksrvailkan
lrkspvakdvdleflakmtngfsgadlteicqracklairesieseirrererqtnpsam
eveeddpvpeirrdhfeeamrfarrsvsdndirkyemfaqtlqqsrgfgsfrfpsgnqgg
agpsqgsgggtggsvytedndddlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ftjB (B:)
nrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllkgkkrreavcivlsddtcsde
kirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpiddtvegitgnlfevylkpyfl
eayrpirkgdiflvrggmravefkvvetdpspycivapdtvihcegepikredeeeslne
vgyddiggcrkqlaqikemvelplrhpalfkaigvkpprgillygppgtgktliaravan
etgaffflingpeimsklagesesnlrkafeeaeknapaiifideldaiapkrekthgev
errivsqlltlmdglkqrahvivmaatnrpnsidpalrrfgrfdrevdigipdatgrlei
lqihtknmkladdvdleqvanethghvgadlaalcseaalqairkkmdlidledetidae
vmnslavtmddfrwalsqsnpsalretvvevpqvtwediggledvkrelqelvqypvehp
dkflkfgmtpskgvlfygppgcgktllakaianecqanfisikgpelltmwfgeseanvr
eifdkarqaapcvlffdeldsiakarggnigdgggaadrvinqiltemdgmstkknvfii
gatnrpdiidpailrpgrldqliyiplpdeksrvailkanlrkspvakdvdleflakmtn
gfsgadlteicqracklairesieseivpeirrdhfeeamrfarrsvsdndirkyemfaq
tlq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5ftjC (C:)
masgadskgddlstailkqknrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllk
gkkrreavcivlsddtcsdekirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpid
dtvegitgnlfevylkpyfleayrpirkgdiflvrggmravefkvvetdpspycivapdt
vihcegepikredeeeslnevgyddiggcrkqlaqikemvelplrhpalfkaigvkpprg
illygppgtgktliaravanetgaffflingpeimsklagesesnlrkafeeaeknapai
ifideldaiapkrekthgeverrivsqlltlmdglkqrahvivmaatnrpnsidpalrrf
grfdrevdigipdatgrleilqihtknmkladdvdleqvanethghvgadlaalcseaal
qairkkmdlidledetidaevmnslavtmddfrwalsqsnpsalretvvevpqvtwedig
gledvkrelqelvqypvehpdkflkfgmtpskgvlfygppgcgktllakaianecqanfi
sikgpelltmwfgeseanvreifdkarqaapcvlffdeldsiakarggnigdgggaadrv
inqiltemdgmstkknvfiigatnrpdiidpailrpgrldqliyiplpdeksrvailkan
lrkspvakdvdleflakmtngfsgadlteicqracklairesieseirrererqtnpsam
eveeddpvpeirrdhfeeamrfarrsvsdndirkyemfaqtlqqsrgfgsfrfpsgnqgg
agpsqgsgggtggsvytedndddlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ftjC (C:)
nrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllkgkkrreavcivlsddtcsde
kirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpiddtvegitgnlfevylkpyfl
eayrpirkgdiflvrggmravefkvvetdpspycivapdtvihcegepikredeeeslne
vgyddiggcrkqlaqikemvelplrhpalfkaigvkpprgillygppgtgktliaravan
etgaffflingpeimsklagesesnlrkafeeaeknapaiifideldaiapkrekthgev
errivsqlltlmdglkqrahvivmaatnrpnsidpalrrfgrfdrevdigipdatgrlei
lqihtknmkladdvdleqvanethghvgadlaalcseaalqairkkmdlidledetidae
vmnslavtmddfrwalsqsnpsalretvvevpqvtwediggledvkrelqelvqypvehp
dkflkfgmtpskgvlfygppgcgktllakaianecqanfisikgpelltmwfgeseanvr
eifdkarqaapcvlffdeldsiakarggnigdgggaadrvinqiltemdgmstkknvfii
gatnrpdiidpailrpgrldqliyiplpdeksrvailkanlrkspvakdvdleflakmtn
gfsgadlteicqracklairesieseivpeirrdhfeeamrfarrsvsdndirkyemfaq
tlq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5ftjD (D:)
masgadskgddlstailkqknrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllk
gkkrreavcivlsddtcsdekirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpid
dtvegitgnlfevylkpyfleayrpirkgdiflvrggmravefkvvetdpspycivapdt
vihcegepikredeeeslnevgyddiggcrkqlaqikemvelplrhpalfkaigvkpprg
illygppgtgktliaravanetgaffflingpeimsklagesesnlrkafeeaeknapai
ifideldaiapkrekthgeverrivsqlltlmdglkqrahvivmaatnrpnsidpalrrf
grfdrevdigipdatgrleilqihtknmkladdvdleqvanethghvgadlaalcseaal
qairkkmdlidledetidaevmnslavtmddfrwalsqsnpsalretvvevpqvtwedig
gledvkrelqelvqypvehpdkflkfgmtpskgvlfygppgcgktllakaianecqanfi
sikgpelltmwfgeseanvreifdkarqaapcvlffdeldsiakarggnigdgggaadrv
inqiltemdgmstkknvfiigatnrpdiidpailrpgrldqliyiplpdeksrvailkan
lrkspvakdvdleflakmtngfsgadlteicqracklairesieseirrererqtnpsam
eveeddpvpeirrdhfeeamrfarrsvsdndirkyemfaqtlqqsrgfgsfrfpsgnqgg
agpsqgsgggtggsvytedndddlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ftjD (D:)
nrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllkgkkrreavcivlsddtcsde
kirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpiddtvegitgnlfevylkpyfl
eayrpirkgdiflvrggmravefkvvetdpspycivapdtvihcegepikredeeeslne
vgyddiggcrkqlaqikemvelplrhpalfkaigvkpprgillygppgtgktliaravan
etgaffflingpeimsklagesesnlrkafeeaeknapaiifideldaiapkrekthgev
errivsqlltlmdglkqrahvivmaatnrpnsidpalrrfgrfdrevdigipdatgrlei
lqihtknmkladdvdleqvanethghvgadlaalcseaalqairkkmdlidledetidae
vmnslavtmddfrwalsqsnpsalretvvevpqvtwediggledvkrelqelvqypvehp
dkflkfgmtpskgvlfygppgcgktllakaianecqanfisikgpelltmwfgeseanvr
eifdkarqaapcvlffdeldsiakarggnigdgggaadrvinqiltemdgmstkknvfii
gatnrpdiidpailrpgrldqliyiplpdeksrvailkanlrkspvakdvdleflakmtn
gfsgadlteicqracklairesieseivpeirrdhfeeamrfarrsvsdndirkyemfaq
tlq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5ftjE (E:)
masgadskgddlstailkqknrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllk
gkkrreavcivlsddtcsdekirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpid
dtvegitgnlfevylkpyfleayrpirkgdiflvrggmravefkvvetdpspycivapdt
vihcegepikredeeeslnevgyddiggcrkqlaqikemvelplrhpalfkaigvkpprg
illygppgtgktliaravanetgaffflingpeimsklagesesnlrkafeeaeknapai
ifideldaiapkrekthgeverrivsqlltlmdglkqrahvivmaatnrpnsidpalrrf
grfdrevdigipdatgrleilqihtknmkladdvdleqvanethghvgadlaalcseaal
qairkkmdlidledetidaevmnslavtmddfrwalsqsnpsalretvvevpqvtwedig
gledvkrelqelvqypvehpdkflkfgmtpskgvlfygppgcgktllakaianecqanfi
sikgpelltmwfgeseanvreifdkarqaapcvlffdeldsiakarggnigdgggaadrv
inqiltemdgmstkknvfiigatnrpdiidpailrpgrldqliyiplpdeksrvailkan
lrkspvakdvdleflakmtngfsgadlteicqracklairesieseirrererqtnpsam
eveeddpvpeirrdhfeeamrfarrsvsdndirkyemfaqtlqqsrgfgsfrfpsgnqgg
agpsqgsgggtggsvytedndddlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ftjE (E:)
nrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllkgkkrreavcivlsddtcsde
kirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpiddtvegitgnlfevylkpyfl
eayrpirkgdiflvrggmravefkvvetdpspycivapdtvihcegepikredeeeslne
vgyddiggcrkqlaqikemvelplrhpalfkaigvkpprgillygppgtgktliaravan
etgaffflingpeimsklagesesnlrkafeeaeknapaiifideldaiapkrekthgev
errivsqlltlmdglkqrahvivmaatnrpnsidpalrrfgrfdrevdigipdatgrlei
lqihtknmkladdvdleqvanethghvgadlaalcseaalqairkkmdlidledetidae
vmnslavtmddfrwalsqsnpsalretvvevpqvtwediggledvkrelqelvqypvehp
dkflkfgmtpskgvlfygppgcgktllakaianecqanfisikgpelltmwfgeseanvr
eifdkarqaapcvlffdeldsiakarggnigdgggaadrvinqiltemdgmstkknvfii
gatnrpdiidpailrpgrldqliyiplpdeksrvailkanlrkspvakdvdleflakmtn
gfsgadlteicqracklairesieseivpeirrdhfeeamrfarrsvsdndirkyemfaq
tlq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5ftjF (F:)
masgadskgddlstailkqknrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllk
gkkrreavcivlsddtcsdekirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpid
dtvegitgnlfevylkpyfleayrpirkgdiflvrggmravefkvvetdpspycivapdt
vihcegepikredeeeslnevgyddiggcrkqlaqikemvelplrhpalfkaigvkpprg
illygppgtgktliaravanetgaffflingpeimsklagesesnlrkafeeaeknapai
ifideldaiapkrekthgeverrivsqlltlmdglkqrahvivmaatnrpnsidpalrrf
grfdrevdigipdatgrleilqihtknmkladdvdleqvanethghvgadlaalcseaal
qairkkmdlidledetidaevmnslavtmddfrwalsqsnpsalretvvevpqvtwedig
gledvkrelqelvqypvehpdkflkfgmtpskgvlfygppgcgktllakaianecqanfi
sikgpelltmwfgeseanvreifdkarqaapcvlffdeldsiakarggnigdgggaadrv
inqiltemdgmstkknvfiigatnrpdiidpailrpgrldqliyiplpdeksrvailkan
lrkspvakdvdleflakmtngfsgadlteicqracklairesieseirrererqtnpsam
eveeddpvpeirrdhfeeamrfarrsvsdndirkyemfaqtlqqsrgfgsfrfpsgnqgg
agpsqgsgggtggsvytedndddlyg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ftjF (F:)
nrpnrlivdeainednsvvslsqpkmdelqlfrgdtvllkgkkrreavcivlsddtcsde
kirmnrvvrnnlrvrlgdvisiqpcpdvkygkrihvlpiddtvegitgnlfevylkpyfl
eayrpirkgdiflvrggmravefkvvetdpspycivapdtvihcegepikredeeeslne
vgyddiggcrkqlaqikemvelplrhpalfkaigvkpprgillygppgtgktliaravan
etgaffflingpeimsklagesesnlrkafeeaeknapaiifideldaiapkrekthgev
errivsqlltlmdglkqrahvivmaatnrpnsidpalrrfgrfdrevdigipdatgrlei
lqihtknmkladdvdleqvanethghvgadlaalcseaalqairkkmdlidledetidae
vmnslavtmddfrwalsqsnpsalretvvevpqvtwediggledvkrelqelvqypvehp
dkflkfgmtpskgvlfygppgcgktllakaianecqanfisikgpelltmwfgeseanvr
eifdkarqaapcvlffdeldsiakarggnigdgggaadrvinqiltemdgmstkknvfii
gatnrpdiidpailrpgrldqliyiplpdeksrvailkanlrkspvakdvdleflakmtn
gfsgadlteicqracklairesieseivpeirrdhfeeamrfarrsvsdndirkyemfaq
tlq