PDB entry 5d8j

View 5d8j on RCSB PDB site
Description: Development of a therapeutic monoclonal antibody targeting secreted aP2 to treat type 2 diabetes.
Class: immune system
Keywords: AP2, Fabp4, Diabetes, metabolic syndrome, immune system
Deposited on 2015-08-17, released 2016-01-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-02, with a file datestamp of 2017-07-28.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fatty acid-binding protein, adipocyte
    Species: Mus musculus [TaxId:10090]
    Gene: Fabp4, Ap2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04117 (2-133)
      • expression tag (1)
    Domains in SCOPe 2.07: d5d8ja1, d5d8ja2
  • Chain 'H':
    Compound: HA3 Fab Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D8J (0-End)
  • Chain 'L':
    Compound: HA3 Fab Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 5D8J (0-End)
    Domains in SCOPe 2.07: d5d8jl1, d5d8jl2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5d8jA (A:)
gsmcdafvgtwklvssenfddymkevgvgfatrkvagmakpnmiisvngdlvtirsestf
knteisfklgvefdeitaddrkvksiitldggalvqvqkwdgksttikrkrdgdklvvec
vmkgvtstrvyera

    Sequence, based on observed residues (ATOM records): (download) 
    >5d8jA (A:)
smcdafvgtwklvssenfddymkevgvgfatrkvagmakpnmiisvngdlvtirsestfk
nteisfklgvefdeitaddrkvksiitldggalvqvqkwdgksttikrkrdgdklvvecv
mkgvtstrvyera

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5d8jL (L:)
evvltqspalmaaspgekvtitcsvsssisssnlhwyqqksetspkpwiygtsnlasgvp
vrfsgsgsgtsysltissmeaedaatyycqqwshypltfgagtklelkrtdaaptvsifp
psseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstl
tltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >5d8jL (L:)
evvltqspalmaaspgekvtitcsvsssisssnlhwyqqksetspkpwiygtsnlasgvp
vrfsgsgsgtsysltissmeaedaatyycqqwshypltfgagtklelkrtdaaptvsifp
psseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstl
tltkdeyerhnsytceathktstspivksfnrne