PDB entry 4xpn

View 4xpn on RCSB PDB site
Description: Crystal Structure of Protein Phosphate 1 complexed with PP1 binding domain of GADD34
Class: hydrolase
Keywords: eIF2alpha phosphatase, PP1 regulator, HYDROLASE
Deposited on 2015-01-17, released 2015-07-01
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-07-01, with a file datestamp of 2015-06-26.
Experiment type: XRAY
Resolution: 2.29 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1CA, PPP1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62136 (5-End)
      • expression tag (2-4)
    Domains in SCOPe 2.05: d4xpna_
  • Chain 'B':
    Compound: Protein phosphatase 1 regulatory subunit 15A
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1R15A, GADD34
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1CA, PPP1A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62136 (5-End)
      • expression tag (4)
    Domains in SCOPe 2.05: d4xpnc_
  • Chain 'D':
    Compound: Protein phosphatase 1 regulatory subunit 15A
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1R15A, GADD34
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MN, PO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xpnA (A:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpad

    Sequence, based on observed residues (ATOM records): (download) 
    >4xpnA (A:)
mgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicg
dihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrg
nhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsm
eqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldl
icrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpa

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4xpnC (C:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpad

    Sequence, based on observed residues (ATOM records): (download) 
    >4xpnC (C:)
slnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicgdi
hgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrgnh
ecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsmeq
irrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldlic
rahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpa

  • Chain 'D':
    No sequence available.