PDB entry 4rn0

View 4rn0 on RCSB PDB site
Description: Crystal structure of S39D HDAC8 in complex with a largazole analogue.
Class: hydrolase/hydrolase inhibitor
Keywords: metalloenzyme, hydrolase, histone deacetylase, enzyme inhibitor complex, largazole analogue, thiol inhibitor, arginase/deacetylase fold, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-10-22, released 2015-04-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-04-22, with a file datestamp of 2015-04-17.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (38)
      • expression tag (377)
    Domains in SCOPe 2.06: d4rn0a1, d4rn0a2
  • Chain 'B':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (38)
      • expression tag (377-381)
    Domains in SCOPe 2.06: d4rn0b1, d4rn0b2
  • Heterogens: L6G, ZN, K, IMD, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rn0A (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rn0A (A:)
lvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegsieyglgydcpategifdyaaaiggatitaaqclidgmckvainwsg
gwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvs
lhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpka
vvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtylt
gvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvvi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rn0B (B:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rn0B (B:)
lvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqhpdsieygldcpategifdyaaaiggatitaaqclidgmckvainwsgg
whhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvsl
hkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkav
vlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltg
vilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvvieg
rg