PDB entry 4rch

View 4rch on RCSB PDB site
Description: Discovery of 2-Pyridyl Ureas as Glucokinase Activators
Class: transferase
Keywords: transferase
Deposited on 2014-09-16, released 2014-10-08
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-10-08, with a file datestamp of 2014-10-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.233
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (24-End)
      • expression tag (22-23)
    Domains in SCOPe 2.04: d4rcha1, d4rcha2
  • Heterogens: GLC, 3LZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rchA (A:)
msghhhhhhassglvprgsmaltlveqilaefqlqeedlkkvmrrmqkemdrglrlethe
easvkmlptyvrstpegsevgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysip
edamtgtaemlfdyisecisdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgf
kasgaegnnvvgllrdaikrrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcn
acymeemqnvelvegdegrmcvntewgafgdsgeldeflleydrlvdessanpgqqlyek
liggkymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiyni
lstlglrpsttdcdivrracesvstraahmcsaglagvinrmresrsedvmritvgvdgs
vyklhpsfkerfhasvrrltpsceitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >4rchA (A:)
tlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpegsevgd
flsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisecisdf
ldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrg
dfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcv
ntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvden
llfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrraces
vstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltps
ceitfieseegsgrgaalvsavackkac