PDB entry 4mmy

View 4mmy on RCSB PDB site
Description: Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif
Class: cell adhesion
Keywords: integrin, A domain, hybrid domain, PSI, EGF repeats, beta TA thigh, beta propeller, RGD motif, fibronectin, vitronectin, CELL ADHESION
Deposited on 2013-09-09, released 2014-03-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 3.18 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Integrin alpha-V
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGAV, MSK8, VNRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4mmya1, d4mmya2, d4mmya3, d4mmya4
  • Chain 'B':
    Compound: integrin beta-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGB3, GP3A
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Fibronectin
    Species: Homo sapiens [TaxId:9606]
    Gene: FN1, FN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02751
      • engineered mutation (74-75)
      • engineered mutation (79-80)
    Domains in SCOPe 2.07: d4mmyc_
  • Heterogens: NAG, BMA, MAN, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mmyA (A:)
fnldvdspaeysgpegsyfgfavdffvpsassrmfllvgapkanttqpgiveggqvlkcd
wsstrrcqpiefdatgnrdyakddplefkshqwfgasvrskqdkilacaplyhwrtemkq
erepvgtcflqdgtktveyapcrsqdidadgqgfcqggfsidftkadrvllggpgsfywq
gqlisdqvaeivskydpnvysikynnqlatrtaqaifddsylgysvavgdfngdgiddfv
sgvpraartlgmvyiydgknmsslynftgeqmaayfgfsvaatdingddyadvfigaplf
mdrgsdgklqevgqvsvslqrasgdfqttklngfevfarfgsaiaplgdldqdgfndiai
aapyggedkkgivyifngrstglnavpsqilegqwaarsmppsfgysmkgatdidkngyp
dlivgafgvdrailyrarpvitvnaglevypsilnqdnktcslpgtalkvscfnvrfclk
adgkgvlprklnfqvellldklkqkgairralflysrspshsknmtisrgglmqceelia
ylrdesefrdkltpitifmeyrldyrtaadttglqpilnqftpanisrqahilldcgedn
vckpklevsvdsdqkkiyigddnpltlivkaqnqgegayeaelivsiplqadfigvvrnn
ealarlscafktenqtrqvvcdlgnpmkagtqllaglrfsvhqqsemdtsvkfdlqiqss
nlfdkvspvvshkvdlavlaaveirgvsspdhvflpipnwehkenpeteedvgpvvqhiy
elrnngpssfskamlhlqwpykynnntllyilhydidgpmnctsdmeinplrikisslqt
tekndtvagqgerdhlitkrdlalsegdihtlgcgvaqclkivcqvgrldrgksailyvk
sllwtetfmnkenqnhsyslkssasfnviefpyknlpieditnstlvttnvtwgiqpap

    Sequence, based on observed residues (ATOM records): (download) 
    >4mmyA (A:)
fnldvdspaeysgpegsyfgfavdffvpsassrmfllvgapkanttqpgiveggqvlkcd
wsstrrcqpiefdatgnrdyakddplefkshqwfgasvrskqdkilacaplyhwrtemkq
erepvgtcflqdgtktveyapcrsqdidadgqgfcqggfsidftkadrvllggpgsfywq
gqlisdqvaeivskydpnvysikynnqlatrtaqaifddsylgysvavgdfngdgiddfv
sgvpraartlgmvyiydgknmsslynftgeqmaayfgfsvaatdingddyadvfigaplf
mdrgsdgklqevgqvsvslqrasgdfqttklngfevfarfgsaiaplgdldqdgfndiai
aapyggedkkgivyifngrstglnavpsqilegqwaarsmppsfgysmkgatdidkngyp
dlivgafgvdrailyrarpvitvnaglevypsilnqdnktcslpgtalkvscfnvrfclk
adgkgvlprklnfqvellldklkqkgairralflysrspshsknmtisrgglmqceelia
ylrdesefrdkltpitifmeyrldyrtaadttglqpilnqftpanisrqahilldcgedn
vckpklevsvdsdqkkiyigddnpltlivkaqnqgegayeaelivsiplqadfigvvrnn
ealarlscafktenqtrqvvcdlgnpmkagtqllaglrfsvhqqsemdtsvkfdlqiqss
nlfdkvspvvshkvdlavlaaveirgvsspdhvflpipnwehkenpeteedvgpvvqhiy
elrnngpssfskamlhlqwpykynnntllyilhydidgpmnctsdmeinplrikidihtl
gcgvaqclkivcqvgrldrgksailyvksllwtetfmnkenqnhsyslkssasfnviefp
yknlpieditnstlvttnvtwgiq

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4mmyC (C:)
sdvprdlevvaatptslliswdapavtvryyritygetggnspvqeftvpgskstatisg
lkpgvdytitvyaviargdwndgskpisinyrtgkkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4mmyC (C:)
viargdwn