PDB entry 4kbk

View 4kbk on RCSB PDB site
Description: CK1d in complex with (3S)-3-{4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]pyridin-2-yl}morpholine inhibitor
Class: transferase/transferase inhibitor
Keywords: ser/thr kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-04-23, released 2013-09-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-09-18, with a file datestamp of 2013-09-13.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.193
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kbka_
  • Chain 'B':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kbkb_
  • Chain 'C':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kbkc_
  • Chain 'D':
    Compound: Casein kinase I isoform delta
    Species: Homo sapiens [TaxId:9606]
    Gene: CSNK1D, HCKID
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4kbkd_
  • Heterogens: 1QG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kbkA (A:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbkA (A:)
lrvgnryrlgrkigsggdiylgtdiaageevaiklecqlhieskiykmmqggvgiptirw
cgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrdvk
pdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlgieq
srrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefat
ylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kbkB (B:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbkB (B:)
lrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqgg
vgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsk
nfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrknltgtaryasint
hlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgy
psefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4kbkC (C:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbkC (C:)
rvgnryrlgrkigsgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
rdvkpdnflmglgkkgnlvyiidfglakkyhipyrenknltgtaryasinthlgieqsrr
ddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatyln
fcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4kbkD (D:)
mhhhhhhssglvprgslrvgnryrlgrkigsgsfgdiylgtdiaageevaiklecvktkh
pqlhieskiykmmqggvgiptirwcgaegdynvmvmellgpsledlfnfcsrkfslktvl
lladqmisrieyihsknfihrdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhip
yrenknltgtaryasinthlgieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkye
risekkmstpievlckgypsefatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydy
vfdwnmlkfgasraaddaererrdreerlrh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kbkD (D:)
lrvgnryrlgrkigdiylgtdiaageevaiklecpqlhieskiykmmqggvgiptirwcg
aegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihrdvkpd
nflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlgieqsr
rddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypsefatyl
nfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnml