PDB entry 4ick

View 4ick on RCSB PDB site
Description: Crystal structure of human AP4A hydrolase E58A mutant
Class: hydrolase
Keywords: Nudix fold, Hydrolase
Deposited on 2012-12-10, released 2013-12-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT2, APAH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50583 (Start-146)
      • engineered mutation (57)
      • expression tag (147-149)
    Domains in SCOPe 2.07: d4icka1, d4icka2
  • Chain 'B':
    Compound: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT2, APAH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50583 (Start-146)
      • engineered mutation (57)
      • expression tag (147)
    Domains in SCOPe 2.07: d4ickb1, d4ickb2
  • Heterogens: GOL, PO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ickA (A:)
malracgliifrrclipkvdnnaieflllqasdgihhwtppkghvepgeddletalratq
eeagieagqltiiegfkrelnyvarnkpktviywlaevkdydveirlshehqayrwlgle
eacqlaqfkemkaalqeghqflcsiealehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4ickA (A:)
racgliifrrclipkvdnnaieflllqasdgihhwtppkghvepgeddletalratqeea
gieagqltiiegfkrelnyvarnkpktviywlaevkdydveirlshehqayrwlgleeac
qlaqfkemkaalqeghqflcsiealeh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ickB (B:)
malracgliifrrclipkvdnnaieflllqasdgihhwtppkghvepgeddletalratq
eeagieagqltiiegfkrelnyvarnkpktviywlaevkdydveirlshehqayrwlgle
eacqlaqfkemkaalqeghqflcsiealehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4ickB (B:)
lracgliifrrclipknaieflllqasdgihhwtppkghvepgeddletalratqeeagi
eagqltiiegfkrelnyvarnkpktviywlaevkdydveirlshehqayrwlgleeacql
aqfkemkaalqeghqflcsieal