PDB entry 4flh

View 4flh on RCSB PDB site
Description: Crystal structure of human PI3K-gamma in complex with AMG511
Class: Transferase/Inhibitor
Keywords: p110, phosphotransferase, cancer, p85, phosphorylation, Transferase-Inhibitor complex
Deposited on 2012-06-14, released 2012-08-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-03, with a file datestamp of 2012-09-28.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.202
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4flha1, d4flha2, d4flha3, d4flha4
  • Heterogens: SO4, 14K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4flhA (A:)
gseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4flhA (A:)
eesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvts
kplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftdfvlrvcgrdeylv
getpiknfqwvrhclkngeeihvvldtppdpaldevrkevslwdcdrkfrvkirgidipv
ldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycg
kvqllyyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisilldpi
alpkhqempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwg
qqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhy
llqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavilea
ylrgcgtamlhdftqqvqviemlqkvtldikslsaedvssqvisqlkqklenlqnsqlpe
sfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqd
mlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntga
fkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlf
hidfghikervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfs
mmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl