SCOPe 2.06: Domain d4flha4: 4flh A:726-1092

Lineage for d4flha4 (4flh A:726-1092)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (65 PDB entries)

8. Domain d4flha4: 4flh A:726-1092 [252036]
   Other proteins in same PDB: d4flha1, d4flha2, d4flha3
   automated match to d1e7ua4
   complexed with 14k, so4

Details for d4flha4

PDB Entry: 4flh, 2.6 Å

PDB Description: crystal structure of human pi3k-gamma in complex with amg511

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4flha4:

Sequence, based on SEQRES records:

>d4flha4 d.144.1.4 (A:726-1092) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlvl

Sequence, based on observed residues (ATOM records):

>d4flha4 d.144.1.4 (A:726-1092) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaedvssqvisqlkqklenlqnsqlpesfrvpy
dpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqi
lrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgh
ikervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtg
mpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl

Timeline for d4flha4:

• d4flha4 first appeared in SCOPe 2.04
  
• d4flha4 appears in SCOPe 2.05
  
• d4flha4 appears in SCOPe 2.07
  
• d4flha4 appears in the current release, SCOPe 2.08