PDB entry 4c8r

View 4c8r on RCSB PDB site
Description: Human gamma-butyrobetaine dioxygenase (BBOX1) in complex with Ni(II) and N-(3-hydroxypicolinoyl)-S-(pyridin-2-ylmethyl)-L-cysteine (AR692B)
Class: oxidoreductase
Keywords: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase 1, dsbh, facial triad, gamma-butyrobetaine, hydroxylase
Deposited on 2013-10-01, released 2014-05-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-05-14, with a file datestamp of 2014-05-09.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: 0.215
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4c8ra1, d4c8ra2
  • Chain 'B':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4c8rb1, d4c8rb2
  • Chain 'C':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4c8rc1, d4c8rc2
  • Chain 'D':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4c8rd1, d4c8rd2
  • Chain 'E':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4c8re1, d4c8re2
  • Chain 'F':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4c8rf1, d4c8rf2
  • Heterogens: NI, ZN, 6YT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4c8rA (A:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4c8rA (A:)
mactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllvealdv
nigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgsel
qlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfyght
wqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcqk
lkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdtif
dvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteisr
hlegayadwdvvmsrlrilrqrve

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4c8rB (B:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4c8rB (B:)
mactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllvealdv
nigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgsel
qlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfyght
wqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcqk
lkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdtif
dvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteisr
hlegayadwdvvmsrlrilrqrve

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4c8rC (C:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4c8rC (C:)
mactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllvealdv
nigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgsel
qlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfyght
wqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcqk
lkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdtif
dvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteisr
hlegayadwdvvmsrlrilrqrve

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4c8rD (D:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4c8rD (D:)
mactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllvealdv
nigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgsel
qlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfyght
wqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcqk
lkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdtif
dvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteisr
hlegayadwdvvmsrlrilrqrve

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4c8rE (E:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4c8rE (E:)
mactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllvealdv
nigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgsel
qlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfyght
wqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcqk
lkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdtif
dvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteisr
hlegayadwdvvmsrlrilrqrve

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4c8rF (F:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4c8rF (F:)
mactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllvealdv
nigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgsel
qlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfyght
wqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcqk
lkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdtif
dvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteisr
hlegayadwdvvmsrlrilrqrve