PDB entry 3ut5

View 3ut5 on RCSB PDB site
Description: Tubulin-Colchicine-Ustiloxin: Stathmin-like domain complex
Class: structural protein/inhibitor
Keywords: Microtubules, Tubulin, Vinca domain, Ustiloxin, Stathmin, STRUCTURAL PROTEIN, STRUCTURAL PROTEIN-INHIBITOR complex
Deposited on 2011-11-25, released 2012-08-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-01-23, with a file datestamp of 2013-01-18.
Experiment type: XRAY
Resolution: 2.73 Å
R-factor: 0.186
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWZ0 (0-End)
      • see remark 999 (231)
      • see remark 999 (339)
    Domains in SCOPe 2.07: d3ut5a1, d3ut5a2
  • Chain 'B':
    Compound: Tubulin beta chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWY9 (0-End)
      • see remark 999 (314-315)
      • see remark 999 (332)
      • see remark 999 (364)
    Domains in SCOPe 2.07: d3ut5b1, d3ut5b2
  • Chain 'C':
    Compound: Tubulin alpha chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWZ0 (0-End)
      • see remark 999 (231)
      • see remark 999 (339)
    Domains in SCOPe 2.07: d3ut5c1, d3ut5c2
  • Chain 'D':
    Compound: Tubulin beta chain
    Species: Ovis aries [TaxId:9940]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D0VWY9 (0-End)
      • see remark 999 (314-315)
      • see remark 999 (332)
      • see remark 999 (364)
    Domains in SCOPe 2.07: d3ut5d1, d3ut5d2
  • Chain 'E':
    Compound: Stathmin-4
    Species: Rattus norvegicus [TaxId:10116]
    Gene: STMN4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63043 (1-End)
      • expression tag (0)
      • engineered mutation (10)
      • engineered mutation (16)
    Domains in SCOPe 2.07: d3ut5e1, d3ut5e2
  • Chain 'F':
    Compound: Vinca tetrapeptide
    Database cross-references and differences (RAF-indexed):
    • PDB 3UT5 (0-3)
  • Heterogens: GTP, MG, SO4, GDP, LOC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ut5A (A:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsvegegeeegeey
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ut5A (A:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsddsfntffsetgagkhvpravf
    vdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirklad
    qctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepyns
    iltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdga
    lnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdp
    rhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggd
    lakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaa
    lekdyeevgvdsv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3ut5B (B:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
    epynatlsvhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvatifrgrmsmkevdeqmlniqnknssyfvewipnnvktavcdipprg
    lkmsstfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatadeqgefeeeegedea
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ut5B (B:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
    epynatlsvhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvatifrgrmsmkevdeqmlniqnknssyfvewipnnvktavcdipprg
    lkmsstfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatade
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3ut5C (C:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
    hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
    rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
    vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
    slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
    qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
    tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
    aredmaalekdyeevgvdsvegegeeegeey
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ut5C (C:)
    mrecisihvgqagvqignacwelyclehgiqpdgqmpsdsfntffsetgagkhvpravfv
    dleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladq
    ctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsi
    ltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgal
    nvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdpr
    hgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdl
    akvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaal
    ekdyeevgvdsv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3ut5D (D:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
    epynatlsvhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvatifrgrmsmkevdeqmlniqnknssyfvewipnnvktavcdipprg
    lkmsstfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatadeqgefeeeegedea
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ut5D (D:)
    mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneatgnkyv
    prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
    rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvmpspkvsdtvv
    epynatlsvhqlventdetysidnealydicfrtlklttptygdlnhlvsatmsgvttcl
    rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdsknmm
    aacdprhgryltvatifrgrmsmkevdeqmlniqnknssyfvewipnnvktavcdipprg
    lkmsstfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
    eyqqyqdatade
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >3ut5E (E:)
    admevielnkatsgqswevilkppsfdgvpefnaslprrrdpsleeiqkkleaaeerrky
    qeaellkhlaekrehereviqkaieennnfikmakeklaqkmesnkenreahlaamlerl
    qekdkhaeevrknkelkeeasr
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ut5E (E:)
    admevielnkatsgqswevilkppsfdgvperrrdpsleeiqkkleaaeerrkyqeaell
    khlaekrehereviqkaieennnfikmakeklaqkmesnkenreahlaamlerlqekdkh
    aeevrknkelke
    

  • Chain 'F':
    No sequence available.