PDB entry 3ox3

View 3ox3 on RCSB PDB site
Description: X-ray Structural study of quinone reductase II inhibition by compounds with micromolar to nanomolar range IC50 values
Class: oxidoreductase
Keywords: qr2, nq02, flavoprotein, metal-2 binding, oxidoreductase, phosphoprotein, fad
Deposited on 2010-09-21, released 2011-05-25
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-06, with a file datestamp of 2011-07-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.187
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3ox3a_
  • Chain 'B':
    Compound: Ribosyldihydronicotinamide dehydrogenase [quinone]
    Species: Homo sapiens [TaxId:9606]
    Gene: NQO2, NMOR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3ox3b_
  • Heterogens: ZN, FAD, 4X4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ox3A (A:)
magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtl
snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ox3A (A:)
gkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtlsn
pevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvlc
qgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcgf
kvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ox3B (B:)
magkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtl
snpevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrv
lcqgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfc
gfkvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfgq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ox3B (B:)
gkkvlivyahqepksfngslknvavdelsrqgctvtvsdlyamnfepratdkditgtlsn
pevfnygvetheaykqrslasditdeqkkvreadlvifqfplywfsvpailkgwmdrvlc
qgfafdipgfydsgllqgklallsvttggtaemytktgvngdsryflwplqhgtlhfcgf
kvlapqisfapeiaseeerkgmvaawsqrlqtiwkeepipctahwhfg