PDB entry 3lvp

View 3lvp on RCSB PDB site
Description: Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor
Class: Transferase
Keywords: protein kinase, tyrosine kinase, tyrosine phosphorylation, protein-substrate complex, Transferase
Deposited on 2010-02-22, released 2010-07-21
The last revision prior to the SCOPe 2.06 freeze date was dated 2010-07-21, with a file datestamp of 2010-07-16.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.226
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3lvpa_
  • Chain 'B':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3lvpb_
  • Chain 'C':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3lvpc_
  • Chain 'D':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3lvpd_
  • Heterogens: PDR, EPE, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lvpA (A:)
lvimlyvfhrkrnnsrlgngvlyasvnpeyfsaadvyvpdewevarekitmsrelgqgsf
gmvyegvakgvvkdepetrvaiktvneaasmrerieflneasvmkefnchhvvrllgvvs
qgqptlvimelmtrgdlksylrslrpemennpvlappslskmiqmageiadgmaylnank
fvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkggkgllpvrwmspeslkdgvft
tysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfelmrmcwq
ynpkmrpsfleiissikeemepgfrevsfyyseenk

    Sequence, based on observed residues (ATOM records): (download) 
    >3lvpA (A:)
pdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmreriefl
neasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemepvlappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyggkgllpvr
wmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdnc
pdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lvpB (B:)
lvimlyvfhrkrnnsrlgngvlyasvnpeyfsaadvyvpdewevarekitmsrelgqgsf
gmvyegvakgvvkdepetrvaiktvneaasmrerieflneasvmkefnchhvvrllgvvs
qgqptlvimelmtrgdlksylrslrpemennpvlappslskmiqmageiadgmaylnank
fvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkggkgllpvrwmspeslkdgvft
tysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfelmrmcwq
ynpkmrpsfleiissikeemepgfrevsfyyseenk

    Sequence, based on observed residues (ATOM records): (download) 
    >3lvpB (B:)
vyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmreri
eflneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpevlappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgg
kgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeggl
ldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseen

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3lvpC (C:)
lvimlyvfhrkrnnsrlgngvlyasvnpeyfsaadvyvpdewevarekitmsrelgqgsf
gmvyegvakgvvkdepetrvaiktvneaasmrerieflneasvmkefnchhvvrllgvvs
qgqptlvimelmtrgdlksylrslrpemennpvlappslskmiqmageiadgmaylnank
fvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkggkgllpvrwmspeslkdgvft
tysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfelmrmcwq
ynpkmrpsfleiissikeemepgfrevsfyyseenk

    Sequence, based on observed residues (ATOM records): (download) 
    >3lvpC (C:)
yvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmrerie
flneasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpevlappslsk
miqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkkgl
lpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldk
pdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3lvpD (D:)
lvimlyvfhrkrnnsrlgngvlyasvnpeyfsaadvyvpdewevarekitmsrelgqgsf
gmvyegvakgvvkdepetrvaiktvneaasmrerieflneasvmkefnchhvvrllgvvs
qgqptlvimelmtrgdlksylrslrpemennpvlappslskmiqmageiadgmaylnank
fvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkggkgllpvrwmspeslkdgvft
tysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfelmrmcwq
ynpkmrpsfleiissikeemepgfrevsfyyseenk

    Sequence, based on observed residues (ATOM records): (download) 
    >3lvpD (D:)
vyvpdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktveflneasvmk
efnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpevlappslskmiqmageia
dgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrkgglpvrwmspes
lkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfe
lmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseen