PDB entry 3hei

View 3hei on RCSB PDB site
Description: Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex
Class: transferase/signaling protein
Keywords: Eph receptor tyrosine kinase, ephrin, Cell membrane, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Membrane, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase, TRANSFERASE-SIGNALING PROTEIN COMPLEX
Deposited on 2009-05-08, released 2009-06-30
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.175
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heia_
  • Chain 'B':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heib_
  • Chain 'C':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heic_
  • Chain 'D':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heid_
  • Chain 'E':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heie_
  • Chain 'F':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heif_
  • Chain 'G':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heig_
  • Chain 'H':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heih_
  • Chain 'I':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heii_
  • Chain 'J':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heij_
  • Chain 'K':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heik_
  • Chain 'L':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heil_
  • Chain 'M':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heim_
  • Chain 'N':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3hein_
  • Chain 'O':
    Compound: Ephrin type-A receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EPHA2, ECK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3heio_
  • Chain 'P':
    Compound: Ephrin-A1
    Species: Homo sapiens [TaxId:9606]
    Gene: EFNA1, EPLG1, LERK1, TNFAIP4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20827 (0-129)
      • expression tag (130-131)
    Domains in SCOPe 2.01: d3heip_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiA (A:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiB (B:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiC (C:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiD (D:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiE (E:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiF (F:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiG (G:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiH (H:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiI (I:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiJ (J:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'K':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiK (K:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiL (L:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiM (M:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiN (N:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiO (O:)
evvlldfaaaggelgwlthpygkgwdlmqnimndmpiymysvcnvmsgdqdnwlrtnwvy
rgeaerifielkftvrdcnsfpggasscketfnlyyaesdldygtnfqkrlftkidtiap
deitvssdfearhvklnveersvgpltrkgfylafqdigacvallsvrvyykkc

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3heiP (P:)
adrhtvfwnssnpkfrnedytihvqlndyvdiicphyedhsvadaameqyilylveheey
qlcqpqskdqvrwqcnrpsakhgpeklsekfqrftpftlgkefkeghsyyyiskpihqhe
drclrlkvtvki