PDB entry 3g76
View 3g76 on RCSB PDB site
Description: Crystal structure of XIAP-BIR3 in complex with a bivalent compound
Class: ligase
Keywords: Apoptosis, IAP, SmacDIABLO, peptidomimetics, pro-apoptotic drugs, Cytoplasm, Ligase, Metal-binding, Phosphoprotein, Polymorphism, Protease inhibitor, Thiol protease inhibitor, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
Deposited on
2009-02-09, released
2009-05-12
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-10-27, with a file datestamp of
2009-10-23.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.235
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76a_ - Chain 'B':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76b1, d3g76b2 - Chain 'C':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76c_ - Chain 'D':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76d1, d3g76d2 - Chain 'E':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76e_ - Chain 'F':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76f1, d3g76f2 - Chain 'G':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76g_ - Chain 'H':
Compound: baculoviral iap repeat-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: XIAP
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3g76h1, d3g76h2 - Heterogens: ZN, CZ3, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3g76A (A:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76A (A:)
nstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwk
psedpweqhakwypgckylleqkgqeyinnihlthsl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3g76B (B:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76B (B:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtth
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3g76C (C:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76C (C:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsl
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3g76D (D:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76D (D:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtth
- Chain 'E':
Sequence, based on SEQRES records: (download)
>3g76E (E:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76E (E:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlths
- Chain 'F':
Sequence, based on SEQRES records: (download)
>3g76F (F:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76F (F:)
nlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkpse
dpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthh
- Chain 'G':
Sequence, based on SEQRES records: (download)
>3g76G (G:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76G (G:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlths
- Chain 'H':
Sequence, based on SEQRES records: (download)
>3g76H (H:)
sdavssdrnfpnstnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkc
fhcgggltdwkpsedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtthhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>3g76H (H:)
stnlprnpsmadyeariftfgtwiysvnkeqlaragfyalgegdkvkcfhcgggltdwkp
sedpweqhakwypgckylleqkgqeyinnihlthsleeclvrtth