PDB entry 2z6w

View 2z6w on RCSB PDB site
Description: Crystal structure of human cyclophilin D in complex with cyclosporin A
Class: isomerase/immunosuppressant
Keywords: isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin d
Deposited on 2007-08-09, released 2008-04-29
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 0.96 Å
R-factor: 0.13
AEROSPACI score: 1.05 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: peptidyl-prolyl cis-trans isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: PPIF, CYP3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30405 (1-164)
      • engineered mutation (132)
    Domains in SCOPe 2.04: d2z6wa_
  • Chain 'B':
    Compound: peptidyl-prolyl cis-trans isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: PPIF, CYP3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30405 (1-164)
      • engineered mutation (132)
    Domains in SCOPe 2.04: d2z6wb_
  • Chain 'M':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'N':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Heterogens: CIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2z6wA (A:)
mgnplvyldvdangkplgrvvlelkadvvpktaenfralctgekgfgykgstfhrvipsf
mcqagdftnhngtggksiygsrfpdenftlkhvgpgvlsmanagpntngsqffictiktd
wldgkhvvfghviegmdvvkkiesfgsksgrtskkivitdcgqls

    Sequence, based on observed residues (ATOM records): (download) 
    >2z6wA (A:)
gnplvyldvdangkplgrvvlelkadvvpktaenfralctgekgfgykgstfhrvipsfm
cqagdftnhngtggksiygsrfpdenftlkhvgpgvlsmanagpntngsqffictiktdw
ldgkhvvfghviegmdvvkkiesfgsksgrtskkivitdcgqls

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2z6wB (B:)
mgnplvyldvdangkplgrvvlelkadvvpktaenfralctgekgfgykgstfhrvipsf
mcqagdftnhngtggksiygsrfpdenftlkhvgpgvlsmanagpntngsqffictiktd
wldgkhvvfghviegmdvvkkiesfgsksgrtskkivitdcgqls

    Sequence, based on observed residues (ATOM records): (download) 
    >2z6wB (B:)
gnplvyldvdangkplgrvvlelkadvvpktaenfralctgekgfgykgstfhrvipsfm
cqagdftnhngtggksiygsrfpdenftlkhvgpgvlsmanagpntngsqffictiktdw
ldgkhvvfghviegmdvvkkiesfgsksgrtskkivitdcgqls

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.