PDB entry 2w1i

View 2w1i on RCSB PDB site
Description: structure determination of aurora kinase in complex with inhibitor
Class: transferase
Keywords: chromosomal rearrangement, nucleotide-binding, tyrosine-protein kinase, proto-oncogene, phosphoprotein, disease mutation, sh2 domain, transferase, ATP-binding, polymorphism, kinase, cancer, aurora, membrane, inhibitor
Deposited on 2008-10-17, released 2009-01-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-01-27, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.209
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: jak2
    Species: HOMO SAPIENS [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W1I
    • Uniprot O60674 (Start-325)
    Domains in SCOPe 2.06: d2w1ia_
  • Chain 'B':
    Compound: jak2
    Species: HOMO SAPIENS [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W1I
    • Uniprot O60674 (Start-325)
    Domains in SCOPe 2.06: d2w1ib_
  • Heterogens: L0I, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w1iA (A:)
msyyhhhhhhdydipttenlyfqgamgsafedrdptqfeerhlkflqqlgkgnfgsvemc
rydplqdntgevvavkklqhsteehlrdfereieilkslqhdnivkykgvcysagrrnlk
limeylpygslrdylqkhkeridhikllqytsqickgmeylgtkryihrdlatrnilven
enrvkigdfgltkvlpqdkeyykvkepgespifwyapeslteskfsvasdvwsfgvvlye
lftyieksksppaefmrmigndkqgqmivfhliellknngrlprpdgcpdeiymimtecw
nnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >2w1iA (A:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w1iB (B:)
msyyhhhhhhdydipttenlyfqgamgsafedrdptqfeerhlkflqqlgkgnfgsvemc
rydplqdntgevvavkklqhsteehlrdfereieilkslqhdnivkykgvcysagrrnlk
limeylpygslrdylqkhkeridhikllqytsqickgmeylgtkryihrdlatrnilven
enrvkigdfgltkvlpqdkeyykvkepgespifwyapeslteskfsvasdvwsfgvvlye
lftyieksksppaefmrmigndkqgqmivfhliellknngrlprpdgcpdeiymimtecw
nnnvnqrpsfrdlalrvdqirdqmag

    Sequence, based on observed residues (ATOM records): (download) 
    >2w1iB (B:)
qfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereieil
kslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag