PDB entry 2vz6

View 2vz6 on RCSB PDB site
Description: structure of human calcium calmodulin dependent protein kinase type II alpha (camk2a) in complex with indirubin e804
Class: transferase
Keywords: transferase, serine/threonine-protein kinase, ATP-binding, cell junction, cell membrane, long term potentiation, brain, kinase, synapse, membrane, nmda receptor signalling, phosphoprotein, calmodulin-binding, nucleotide-binding
Deposited on 2008-07-30, released 2008-08-26
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-08-10, with a file datestamp of 2011-08-05.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.165
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: calcium calmodulin dependent protein kinase type II alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VZ6 (Start-22)
    • Uniprot Q9UQM7 (23-End)
    Domains in SCOPe 2.04: d2vz6a_
  • Chain 'B':
    Compound: calcium calmodulin dependent protein kinase type II alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VZ6 (Start-22)
    • Uniprot Q9UQM7 (23-End)
    Domains in SCOPe 2.04: d2vz6b_
  • Heterogens: FEF, PGO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vz6A (A:)
mhhhhhhssgvdlgtenlyfqsmyqlfeelgkgafsvvrrcvkvlagqeyaakiintkkl
sardhqklerearicrllkhpnivrlhdsiseeghhylifdlvtggelfedivareyyse
adashciqqileavlhchqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqa
wfgfagtpgylspevlrkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikaga
ydfpspewdtvtpeakdlinkmltinpskritaaealkhpwishrstvascmhrqetvdc
lkkfnarrklkga

    Sequence, based on observed residues (ATOM records): (download) 
    >2vz6A (A:)
lyfqsmyqlfeelgkfsvvrrcvkvlagqeyaakiintkklsardhqklerearicrllk
hpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlhchq
mgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevlrkd
pygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakdli
nkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vz6B (B:)
mhhhhhhssgvdlgtenlyfqsmyqlfeelgkgafsvvrrcvkvlagqeyaakiintkkl
sardhqklerearicrllkhpnivrlhdsiseeghhylifdlvtggelfedivareyyse
adashciqqileavlhchqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqa
wfgfagtpgylspevlrkdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikaga
ydfpspewdtvtpeakdlinkmltinpskritaaealkhpwishrstvascmhrqetvdc
lkkfnarrklkga

    Sequence, based on observed residues (ATOM records): (download) 
    >2vz6B (B:)
lyfqsmyqlfeelgkgafsvvrrcvkvlagqeyaakiintkklsardhqklerearicrl
lkhpnivrlhdsiseeghhylifdlvtggelfedivareyyseadashciqqileavlhc
hqmgvvhrdlkpenlllasklkgaavkladfglaievegeqqawfgfagtpgylspevlr
kdpygkpvdlwacgvilyillvgyppfwdedqhrlyqqikagaydfpspewdtvtpeakd
linkmltinpskritaaealkhpwishrstvascmhrqetvdclkkfnarrklk