PDB entry 2oi0

View 2oi0 on RCSB PDB site
Description: Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide
Class: hydrolase
Keywords: TNF-a Coverting enzyme, Aryl-sulfonamide, TACE inhibitors, HYDROLASE
Deposited on 2007-01-10, released 2007-11-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.213
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TNF- a Converting Enzyme (TACE)
    Species: Homo sapiens [TaxId:9606]
    Gene: TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536 (0-261)
      • engineered (50)
      • engineered (236)
      • expression tag (262-265)
    Domains in SCOPe 2.06: d2oi0a2, d2oi0a3
  • Heterogens: ZN, 283, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2oi0A (A:)
adpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgy
giqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcla
hlftyqdfdmgtlglayvgspranshggvcpkayyspvgkkniylnsgltstknygktil
tkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcsk
qsiyktieskaqecfqersnkviegr