PDB entry 2nn6

View 2nn6 on RCSB PDB site
Description: Structure of the human RNA exosome composed of Rrp41, Rrp45, Rrp46, Rrp43, Mtr3, Rrp42, Csl4, Rrp4, and Rrp40
Class: hydrolase/transferase
Keywords: RNA, exosome, PM/Scl, exoribonuclease, phosphorolytic, ribonuclease, HYDROLASE/TRANSFERASE COMPLEX
Deposited on 2006-10-23, released 2006-12-26
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 3.35 Å
R-factor: 0.291
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polymyositis/scleroderma autoantigen 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PMSCL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6a1, d2nn6a2
  • Chain 'B':
    Compound: Exosome complex exonuclease RRP41
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC4, RRP41, SKI6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6b1, d2nn6b2
  • Chain 'C':
    Compound: Exosome complex exonuclease RRP43
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC8, OIP2, RRP43
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6c1, d2nn6c2
  • Chain 'D':
    Compound: Exosome complex exonuclease RRP46
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC5, CML28, RRP46
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6d1, d2nn6d2
  • Chain 'E':
    Compound: Exosome complex exonuclease RRP42
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC7, KIAA0116, RRP42
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15024
      • variant (287)
    Domains in SCOPe 2.01: d2nn6e1, d2nn6e2
  • Chain 'F':
    Compound: Exosome component 6
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC6
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6f1, d2nn6f2
  • Chain 'G':
    Compound: exosome complex exonuclease rrp40
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC3, RRP40
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6g1, d2nn6g2, d2nn6g3
  • Chain 'H':
    Compound: Exosome complex exonuclease RRP4
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC2, RRP4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6h1, d2nn6h2, d2nn6h3
  • Chain 'I':
    Compound: 3'-5' exoribonuclease CSL4 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOSC1, CSL4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2nn6i1, d2nn6i2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2nn6A (A:)
mgsshhhhhhsqdpnshmketplsncerrfllraieekkrldgrqtydyrnirisfgtdy
gccivelgktrvlgqvscelvspklnrategilffnlelsqmaapafepgrqsdllvkln
rlmerclrnskcidteslcvvagekvwqirvdlhllnhdgniidaasiaaivalchfrrp
dvsvqgdevtlytpeerdpvplsihhmpicvsfaffqqgtyllvdpnereervmdgllvi
amnkhreictiqssggimllkdqvlrcskiagvkvaeitelilkalendqkvrkeggkfg
faesianqritafkmekapxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6A (A:)
mketplsncerrfllraieekkrldgrqtydyrnirisfgtdygccivelgktrvlgqvs
celvspklnrategilffnlelsqmaapafepgrqsdllvklnrlmerclrnskcidtes
lcvvagekvwqirvdlhllnhdgniidaasiaaivalchfrrpdvsvqgdevtlytpeer
dpvplsihhmpicvsfaffqqgtyllvdpnereervmdgllviamnkhreictiqssggi
mllkdqvlrcskiagvkvaeitelilkalendqkvrkeggkfgfaesianqritafkmek
apxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2nn6B (B:)
madpmaglellsdqgyrvdgrragelrkiqarmgvfaqadgsayieqgntkalavvygph
eirgsraralpdralvncqyssatfstgerkrrphgdrkscemglqlrqtfeaailtqlh
prsqidiyvqvlqadggtyaacvnaatlavldagipmrdfvcacsagfvdgtaladlshv
eeaaggpqlalallpasgqiallemdarlhedhlervleaaaqaardvhtlldrvvrqhv
reasillgd

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6B (B:)
lsdqgyrvdgrragelrkiqarmgvfaqadgsayieqgntkalavvygpheirgsraral
pdralvncqyssatfstgerkrrphgdrkscemglqlrqtfeaailtqlhprsqidiyvq
vlqadggtyaacvnaatlavldagipmrdfvcacsagfvdgtaladlshveeaaggpqla
lallpasgqiallemdarlhedhlervleaaaqaardvhtlldrvvrqhvreasi

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2nn6C (C:)
dpmaagfktvepleyyrrflkencrpdgrelgefrtttvnigsistadgsalvklgnttv
icgvkaefaapstdapdkgyvvpnvdlpplcssrfrsgppgeeaqvasqfiadviensqi
iqkedlcispgklvwvlycdlicldydgnildactfallaalknvqlpevtineetalae
vnlkkksylnirthpvatsfavfddtllivdptgeeehlatgtltivmdeegklcclhkp
ggsgltgaklqdcmsravtrhkevkklmdeviksmkpk

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6C (C:)
tvepleyyrrflkencrpdgrelgefrtttvnigsistadgsalvklgnttvicgvkaef
aapstdapdkgyvvpnvdlpplcssrfrsgppgeeaqvasqfiadviensqiiqkedlci
spgklvwvlycdlicldydgnildactfallaalknvqlpevtineetalaevnlkkksy
lnirthpvatsfavfddtllivdptgeeehlatgtltivmdeegklcclhkpggsgltga
klqdcmsravtrhkevkklmdeviksmkpk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2nn6D (D:)
slmeeethtdakiraengtgssprgpgcslrhfaceqnllsrpdgsasflqgdtsvlagv
ygpaevkvskeifnkatlevilrpkiglpgvaeksrerlirntceavvlgtlhprtsitv
vlqvvsdagsllacclnaacmalvdagvpmralfcgvacaldsdgtlvldptskqekear
avltfaldsverkllmsstkglysdtelqqclaaaqaasqhvfrfyreslqrrysks

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6D (D:)
gcslrhfaceqnllsrpdgsasflqgdtsvlagvygpaevknkatlevilrpkiglpgva
eksrerlirntceavvlgtlhprtsitvvlqvvsdagsllacclnaacmalvdagvpmra
lfcgvacaldsdgtlvldptskqekearavltfaldsverkllmsstkglysdtelqqcl
aaaqaasqhvfrfyreslqrrysks

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2nn6E (E:)
mgsshhhhhhsqdpmasvtlseaekvyivhgvqedlrvdgrgcedyrcvevetdvvsnts
gsarvklghtdilvgvkaemgtpklekpnegyleffvdcsasatpefegrggddlgteia
ntlyrifnnkssvdlktlcisprehcwvlyvdvlllecggnlfdaisiavkaalfntrip
rvrvledeegskdielsddpydcirlsvenvpcivtlckigyrhvvdatlqeeacslasl
lvsvtskgvvtcmrkvgkgsldpesifemmetgkrvgkvlhaslqsvvhkeeslgpkrqk
vgflg

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6E (E:)
tlseaekvyivhgvqedlrvdgrgcedyrcvevetdvvsntsgsarvklghtdilvgvka
emgtpklekpnegyleffvdcsasatpefegrggddlgteiantlyrifnnkssvdlktl
cisprehcwvlyvdvlllecggnlfdaisiavkaalfntriprvrvledielsddpydci
rlsvenvpcivtlckigyrhvvdatlqeeacslasllvsvtskgvvtcmrkvgkgsldpe
sifemmetgkrvgkvlhaslqsvvhkeeslgpkrq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2nn6F (F:)
mpgdhrrirgpeesqppqlyaadeeeapgtrdptrlrpvyaragllsqakgsayleaggt
kvlcavsgprqaeggergggpagaggeapaalrgrllcdfrrapfagrrrrappggceer
elalalqealepavrlgrypraqlevsallledggsalaaaltaaalaladagvemydlv
vgcglslapgpaptwlldptrleeeraaagltvalmpvlnqvagllgsgegglteswaea
vrlglegcqrlypvlqqslvraarrrgaaaqp

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6F (F:)
gtrdptrlrpvyaragllsqakgsayleaggtkvlcavsgprqalrgrllcdfrrapfag
rrrrappggceerelalalqealepavrlgrypraqlevsallledggsalaaaltaaal
aladagvemydlvvgcglslapgpaptwlldptrleeeraaagltvalmpvlnqvagllg
sgegglteswaeavrlglegcqrlypvlqqslvraarrrgaaa

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2nn6G (G:)
mgsshhhhhhsqdpmaepasvaaeslagsraraartvlgqvvlpgeelllpeqedaegpg
gaverplslnaracsrvrvvcgpglrrcgdrllvtkcgrlrhkepgsgsgggvywvdsqq
kryvpvkgdhvigivtaksgdifkvdvggsepaslsylsfegatkrnrpnvqvgdliygq
fvvankdmepemvcidscgrangmgvigqdgllfkvtlglirkllapdceiiqevgklyp
leivfgmngriwvkaktiqqtlilanileacehmtsdqrkqifsrlaes

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6G (G:)
araartvlgqvvlpgeelllpeqedaegpggavergdrllvtkcgrlrhkepgsgsgggv
ywvdsqqkryvpvkgdhvigivtaksgdifkvdvggsepaslsylsfegatkrnrpnvqv
gdliygqfvvankdmepemvcidscgrangmgvigqdgllfkvtlglirkllapdceiiq
evgklypleivfgmngriwvkaktiqqtlilanileacehmtsdqrkqifsrlaes

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2nn6H (H:)
mgsshhhhhhsqdphmamemrlpvarkplserlgrdtkkhlvvpgdtittdtgfmrghgt
ymgeekliasvagsvervnklicvkalktryigevgdivvgritevqqkrwkvetnsrld
svlllssmnlpggelrrrsaedelamrgflqegdlisaevqavfsdgavslhtrslkygk
lgqgvlvqvspslvkrqkthfhdlpcgasvilgnngfiwiyptpehkeeeaggfianlep
vsladrevisrlrnciislvtqrmmlydtsilycyeaslphqikdilkpeimeeivmetr
qrlleqeg

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6H (H:)
hlvvpgdtittdtgfmrghgtymgeekliasvagsvervnklicvkalktryigevgdiv
vgritevqqkrwkvetnsrldsvlllssmnelamrgflqegdlisaevqavfsdgavslh
trslkygklgqgvlvqvspslvkrqkthfhdlpcgasvilgnngfiwiyptpehgfianl
epvsladrevisrlrnciislvtqrmmlydtsilycyeaslphqikdilkpeimeeivme
trqrlleqeg

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2nn6I (I:)
mgsshhhhhhsqdpmappvrycipgerlcnleegspgsgtytrhgyifsslagclmksse
ngalpvvsvvretesqllpdvgaivtckvssinsrfakvhilyvgsmplknsfrgtirke
dvratekdkveiyksfrpgdivlakvislgdaqsnyllttaenelgvvvahsesgiqmvp
iswcemqcpkthtkefrkvarvqpeflqt

    Sequence, based on observed residues (ATOM records): (download) 
    >2nn6I (I:)
rycipgerlcnleegspgsgtytrhgyifsslagclmkssengalpvvsvvretesqllp
dvgaivtckvssinsrfakvhilyvgsmplknsfrgtirkedvratekdkveiyksfrpg
divlakvislgdaqsnyllttaenelgvvvahsesgiqmvpiswcemqcpkthtkefrkv