PDB entry 2j6w

View 2j6w on RCSB PDB site
Description: r164n mutant of the runx1 runt domain
Class: transcription
Keywords: transcription factor, transcription/DNA, chloride binding, acute myeloid leukemia, transcription regulation, transcription, nuclear protein, phosphorylation, aml, runx1, ig fold, runt domain, DNA-binding
Deposited on 2006-10-04, released 2007-10-09
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-08-10, with a file datestamp of 2011-08-05.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.214
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: runt-related transcription factor 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03347
      • engineered mutation (26)
      • engineered mutation (35)
      • engineered mutation (118)
    Domains in SCOPe 2.01: d2j6wa_
  • Chain 'B':
    Compound: runt-related transcription factor 1
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03347
      • engineered mutation (26)
      • engineered mutation (35)
      • engineered mutation (118)
    Domains in SCOPe 2.01: d2j6wb_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2j6wA (A:)
sgdrsmvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtv
magndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhna
ikitvdgpreprrhrqkldd

    Sequence, based on observed residues (ATOM records): (download) 
    >2j6wA (A:)
smvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtvmagn
denysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhnaikit
vdgp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2j6wB (B:)
sgdrsmvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtv
magndenysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhna
ikitvdgpreprrhrqkldd

    Sequence, based on observed residues (ATOM records): (download) 
    >2j6wB (B:)
smvevladhpgelvrtdspnflssvlpthwrsnktlpiafkvvalgdvpdgtlvtvmagn
denysaelrnataamknqvarfndlrfvgrsgrgksftltitvftnppqvatyhnaikit
vdgp