PDB entry 2itk

View 2itk on RCSB PDB site
Description: human Pin1 bound to D-PEPTIDE
Class: isomerase/isomerase inhibitor
Keywords: Pin1, isomerase, WW domain, ISOMERASE-ISOMERASE INHIBITOR COMPLEX
Deposited on 2006-10-19, released 2007-05-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: 0.223
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PIN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13526 (Start-166)
      • engineered mutation (17)
    Domains in SCOPe 2.07: d2itka1, d2itka2
  • Chain 'B':
    Compound: D-Peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 2ITK
  • Heterogens: PE4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2itkA (A:)
gshgmadeeklppgwekamsrssgrvyyfnhitnasqwerpsgnsssggkngqgeparvr
cshllvkhsqsrrpsswrqekitrtkeealelingyiqkiksgeedfeslasqfsdcssa
kargdlgafsrgqmqkpfedasfalrtgemsgpvftdsgihiilrte

    Sequence, based on observed residues (ATOM records): (download) 
    >2itkA (A:)
lppgwekamsrssgrvyyfnhitnasqwerpseparvrcshllvkhsqsrrpsswrqeki
trtkeealelingyiqkiksgeedfeslasqfsdcssakargdlgafsrgqmqkpfedas
falrtgemsgpvftdsgihiilrte

  • Chain 'B':
    No sequence available.