PDB entry 2ik8

View 2ik8 on RCSB PDB site
Description: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1
Class: signaling protein
Keywords: G protein signalling, RGS, heterotrimeric G protein, signalling complex, Structural Genomics, Structural Genomics Consortium, SGC, SIGNALING PROTEIN
Deposited on 2006-10-02, released 2006-11-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.71 Å
R-factor: 0.235
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i), alpha-1 subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ik8a1, d2ik8a2
  • Chain 'B':
    Compound: Regulator of G-protein signaling 16
    Species: Homo sapiens [TaxId:9606]
    Gene: RGS16, RGSR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ik8b1
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(i), alpha-1 subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAI1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ik8c1, d2ik8c2
  • Chain 'D':
    Compound: Regulator of G-protein signaling 16
    Species: Homo sapiens [TaxId:9606]
    Gene: RGS16, RGSR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2ik8d_
  • Heterogens: ALF, MG, SO4, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ik8A (A:)
arevkllllgagesgkstivkqmkiiheagyseeeckqykavvysntiqsiiaiiramgr
lkidfgdsaraddarqlfvlagaaeegfmtaelagvikrlwkdsgvqacfnrsreyqlnd
saayylndldriaqpnyiptqqdvlrtrvkttgivethftfkdlhfkmfdvggqrserkk
wihcfegvtaiifcvalsdydlvlaedeemnrmhesmklfdsicnnkwftdtsiilflnk
kdlfeekikksplticypeyagsntyeeaaayiqcqfedlnkrkdtkeiythftcatdtk
nvqfvfdavtdviiknnlkdcglf

    Sequence, based on observed residues (ATOM records): (download) 
    >2ik8A (A:)
revkllllgagesgkstivkqmkiiheagyseeeckqykavvysntiqsiiaiiramgrl
kidfgdsaraddarqlfvlamtaelagvikrlwkdsgvqacfnrsreyqlndsaayylnd
ldriaqpnyiptqqdvlrtrvkttgivethftfkdlhfkmfdvggqrserkkwihcfegv
taiifcvalsdydlvlaedeemnrmhesmklfdsicnnkwftdtsiilflnkkdlfeeki
kksplticypeyagsntyeeaaayiqcqfedlnkrkdtkeiythftcatdtknvqfvfda
vtdviiknnl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ik8B (B:)
smrnfsedvlgwresfdlllsskngvaafhaflktefseenlefwlaceefkkirsatkl
asrahqifeeficseapkevnidhetreltrmnlqtatatcfdaaqgktrtlmekdsypr
flkspayrdlaaqasaasat

    Sequence, based on observed residues (ATOM records): (download) 
    >2ik8B (B:)
sfdlllsskngvaafhaflktefseenlefwlaceefkkirsatklasrahqifeefics
eapkevnidhetreltrmnlqtatatcfdaaqgktrtlmekdsyprflkspayrdlaaqa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2ik8C (C:)
arevkllllgagesgkstivkqmkiiheagyseeeckqykavvysntiqsiiaiiramgr
lkidfgdsaraddarqlfvlagaaeegfmtaelagvikrlwkdsgvqacfnrsreyqlnd
saayylndldriaqpnyiptqqdvlrtrvkttgivethftfkdlhfkmfdvggqrserkk
wihcfegvtaiifcvalsdydlvlaedeemnrmhesmklfdsicnnkwftdtsiilflnk
kdlfeekikksplticypeyagsntyeeaaayiqcqfedlnkrkdtkeiythftcatdtk
nvqfvfdavtdviiknnlkdcglf

    Sequence, based on observed residues (ATOM records): (download) 
    >2ik8C (C:)
evkllllgagesgkstivkqmkiiheagyseeeckqykavvysntiqsiiaiiramgrlk
idfgdsaraddarqlfvlamtaelagvikrlwkdsgvqacfnrsreyqlndsaayylndl
driaqpnyiptqqdvlrtrvkttgivethftfkdlhfkmfdvggqrserkkwihcfegvt
aiifcvalsdydlvlaedeemnrmhesmklfdsicnnkwftdtsiilflnkkdlfeekik
ksplticypeyagsntyeeaaayiqcqfedlnkrkdtkeiythftcatdtknvqfvfdav
tdviiknnl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ik8D (D:)
smrnfsedvlgwresfdlllsskngvaafhaflktefseenlefwlaceefkkirsatkl
asrahqifeeficseapkevnidhetreltrmnlqtatatcfdaaqgktrtlmekdsypr
flkspayrdlaaqasaasat

    Sequence, based on observed residues (ATOM records): (download) 
    >2ik8D (D:)
fsedvlgwresfdlllsskngvaafhaflktefseenlefwlaceefkkirsatklasra
hqifeeficseapkevnidhetreltrmnlqtatatcfdaaqgktrtlmekdsyprflks
payrdlaaqa