PDB entry 2egh

View 2egh on RCSB PDB site
Description: Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with a magnesium ion, NADPH and fosmidomycin
Class: Oxidoreductase
Keywords: Protein-inhibitor complex
Deposited on 2007-03-01, released 2007-06-19
The last revision prior to the SCOP 1.73 freeze date was dated 2007-06-19, with a file datestamp of 2007-06-15.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.218
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Species: Escherichia coli
    Gene: dxr
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45568 (11-407)
      • cloning artifact (10)
      • cloning artifact (408-409)
    Domains in SCOP 1.73: d2egha1, d2egha2, d2egha3
  • Chain 'B':
    Compound: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Species: Escherichia coli
    Gene: dxr
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45568 (11-407)
      • cloning artifact (10)
    Domains in SCOP 1.73: d2eghb1, d2eghb2, d2eghb3
  • Heterogens: MG, FOM, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2eghA (A:)
mrgshhhhhhgkqltilgstgsigcstldvvrhnpehfrvvalvagknvtrmveqclefs
pryavmddeasakllktmlqqqgsrtevlsgqqaacdmaaledvdqvmaaivgaagllpt
laairagktillankeslvtcgrlfmdavkqskaqllpvdsehnaifqslpqpiqhnlgy
adleqngvvsilltgsggpfretplrdlatmtpdqacrhpnwsmgrkisvdsatmmnkgl
eyiearwlfnasasqmevlihpqsvihsmvryqdgsvlaqlgepdmrtpiahtmawpnrv
nsgvkpldfcklsaltfaapdydrypclklameafeqgqaattalnaaneitvaaflaqq
irftdiaalnlsvlekmdmrepqcvddvlsvdanarevarkevmrlassacdlgtpgrpa
akln

    Sequence, based on observed residues (ATOM records): (download) 
    >2eghA (A:)
gkqltilgstgsigcstldvvrhnpehfrvvalvagknvtrmveqclefspryavmddea
sakllktmlqqqgsrtevlsgqqaacdmaaledvdqvmaaivgaagllptlaairagkti
llankeslvtcgrlfmdavkqskaqllpvdsehnaifqslpqpiqhnlgyadleqngvvs
illtgsggpfretplrdlatmtpdqacrhpnwsmgrkisvdsatmmnkgleyiearwlfn
asasqmevlihpqsvihsmvryqdgsvlaqlgepdmrtpiahtmawpnrvnsgvkpldfc
klsaltfaapdydrypclklameafeqgqaattalnaaneitvaaflaqqirftdiaaln
lsvlekmdmrepqcvddvlsvdanarevarkevmrlassa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2eghB (B:)
mrgshhhhhhgkqltilgstgsigcstldvvrhnpehfrvvalvagknvtrmveqclefs
pryavmddeasakllktmlqqqgsrtevlsgqqaacdmaaledvdqvmaaivgaagllpt
laairagktillankeslvtcgrlfmdavkqskaqllpvdsehnaifqslpqpiqhnlgy
adleqngvvsilltgsggpfretplrdlatmtpdqacrhpnwsmgrkisvdsatmmnkgl
eyiearwlfnasasqmevlihpqsvihsmvryqdgsvlaqlgepdmrtpiahtmawpnrv
nsgvkpldfcklsaltfaapdydrypclklameafeqgqaattalnaaneitvaaflaqq
irftdiaalnlsvlekmdmrepqcvddvlsvdanarevarkevmrlassacdlgtpgrpa
akln

    Sequence, based on observed residues (ATOM records): (download) 
    >2eghB (B:)
gkqltilgstgsigcstldvvrhnpehfrvvalvagknvtrmveqclefspryavmddea
sakllktmlqqqgsrtevlsgqqaacdmaaledvdqvmaaivgaagllptlaairagkti
llankeslvtcgrlfmdavkqskaqllpvdsehnaifqslpqpiqhnlgyadleqngvvs
illtgsggpfretplrdlatmtpdqacrhpnwsmgrkisvdsatmmnkgleyiearwlfn
asasqmevlihpqsvihsmvryqdgsvlaqlgepdmrtpiahtmawpnrvnsgvkpldfc
klsaltfaapdydrypclklameafeqgqaattalnaaneitvaaflaqqirftdiaaln
lsvlekmdmrepqcvddvlsvdanarevarkevmrlas