PDB entry 2ec9

View 2ec9 on RCSB PDB site
Description: Crystal structure analysis of human Factor VIIa , Souluble tissue factor complexed with BCX-3607
Class: blood clotting
Keywords: protein-cofactor complex, FVIIa and souluble tissue factor, inhibitor, BLOOD CLOTTING
Deposited on 2007-02-13, released 2008-02-19
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-09-05, with a file datestamp of 2012-08-31.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.242
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ec9h_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ec9l1, d2ec9l2, d2ec9l3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
  • Chain 'U':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2ec9u_
  • Heterogens: ASO, FUC, CA, 24X, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2ec9H (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2ec9L (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipile
    

  • Chain 'T':
    No sequence available.

  • Chain 'U':
    Sequence, based on SEQRES records: (download)
    >2ec9U (U:)
    eplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedertlvrrnntflslrdvfgkd
    liytlyywkssssgkktaktntneflidvdkgenycfsvqavipsrtvnrkstdspvecm
    

    Sequence, based on observed residues (ATOM records): (download)
    >2ec9U (U:)
    eplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedertlvrrnntflslrdvfgkd
    liytlyywsgkktaktntneflidvdkgenycfsvqavipsrtvnrkstdspvecm