PDB entry 1xxx

View 1xxx on RCSB PDB site
Description: Crystal structure of Dihydrodipicolinate Synthase (DapA, Rv2753c) from Mycobacterium tuberculosis
Class: lyase
Keywords: dihydrodipicolinate synthase, DapA, Rv2753c, Mycobacterium tuberculosis, lysine biosynthesis, Structural Genomics, PSI, Protein Structure Initiative, TB Structural Genomics Consortium, TBSGC, LYASE
Deposited on 2004-11-09, released 2006-02-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: 0.149
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxa1
  • Chain 'B':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxb_
  • Chain 'C':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxc_
  • Chain 'D':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxd_
  • Chain 'E':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxe_
  • Chain 'F':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxf_
  • Chain 'G':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxg_
  • Chain 'H':
    Compound: Dihydrodipicolinate synthase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: dapA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xxxh_
  • Heterogens: MG, CL, DTT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xxxA (A:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxA (A:)
gfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdg
ekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrg
lqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqim
adtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniav
aplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xxxB (B:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxB (B:)
fdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdge
kiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrgl
qahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqima
dtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniava
plcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1xxxC (C:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxC (C:)
gfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdg
ekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrg
lqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqim
adtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniav
aplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1xxxD (D:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxD (D:)
fdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdge
kiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrgl
qahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqima
dtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniava
plcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1xxxE (E:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxE (E:)
fdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdge
kiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrgl
qahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqima
dtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniava
plcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1xxxF (F:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxF (F:)
gfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdg
ekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrg
lqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqim
adtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniav
aplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1xxxG (G:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxG (G:)
fdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdge
kiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrgl
qahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqima
dtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniava
plcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1xxxH (H:)
gamvttvgfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttge
sptttdgekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyy
skppqrglqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadl
hsgaqimadtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiata
rkiniavaplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraas
vlr

    Sequence, based on observed residues (ATOM records): (download) 
    >1xxxH (H:)
gfdvaarlgtlltamvtpfsgdgsldtataarlanhlvdqgcdglvvsgttgesptttdg
ekiellravleavgdrarviagagtydtahsirlakacaaegahgllvvtpyyskppqrg
lqahftavadatelpmllydipgrsavpiepdtiralashpnivgvkdakadlhsgaqim
adtglayysgddalnlpwlamgatgfisviahlaagqlrellsafgsgdiatarkiniav
aplcnamsrlggvtlskaglrlqgidvgdprlpqvaatpeqidalaadmraasvlr