PDB entry 1wdw

View 1wdw on RCSB PDB site
Description: Structural basis of mutual activation of the tryptophan synthase a2b2 complex from a hyperthermophile, Pyrococcus furiosus
Class: lyase
Keywords: alpha/beta, alpha+beta, RIKEN Structural Genomics/Proteomics Initiative, RSGI, Structural Genomics, LYASE
Deposited on 2004-05-19, released 2005-07-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.196
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tryptophan synthase alpha chain
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwa_
  • Chain 'B':
    Compound: Tryptophan synthase beta chain 1
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwb_
  • Chain 'C':
    Compound: tryptophan synthase alpha chain
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwc_
  • Chain 'D':
    Compound: Tryptophan synthase beta chain 1
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwd_
  • Chain 'E':
    Compound: tryptophan synthase alpha chain
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwe_
  • Chain 'F':
    Compound: Tryptophan synthase beta chain 1
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwf_
  • Chain 'G':
    Compound: tryptophan synthase alpha chain
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwg_
  • Chain 'H':
    Compound: Tryptophan synthase beta chain 1
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwh_
  • Chain 'I':
    Compound: tryptophan synthase alpha chain
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwi_
  • Chain 'J':
    Compound: Tryptophan synthase beta chain 1
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwj_
  • Chain 'K':
    Compound: tryptophan synthase alpha chain
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: trpA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwk_
  • Chain 'L':
    Compound: Tryptophan synthase beta chain 1
    Species: Pyrococcus furiosus [TaxId:2261]
    Gene: TrpB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1wdwl_
  • Heterogens: PLP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wdwA (A:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygttgareeipktay
dllrrakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkk
kveellgi

    Sequence, based on observed residues (ATOM records): (download) 
    >1wdwA (A:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslyeeipktaydllrra
kricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkkkveell
g

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwB (B:)
mwfgefggqyvpetlieplkelekaykrfkddeefnrqlnyylktwagrptplyyakrlt
ekiggakiylkredlvhggahktnnaigqallakfmgktrliaetgagqhgvatamagal
lgmkvdiymgaedverqkmnvfrmkllganvipvnsgsrtlkdainealrdwvatfeyth
yligsvvgphpyptivrdfqsvigreakaqileaegqlpdvivacvgggsnamgifypfv
ndkkvklvgveaggkglesgkhsaslnagqvgvfhgmlsyflqdeegqikpthsiapgld
ypgvgpehaylkkiqraeyvtvtdeealkafhelsrtegiipalesahavayamklakem
srdeiiivnlsgrgdkdldivlkvs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1wdwC (C:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygttgareeipktay
dllrrakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkk
kveellgi

    Sequence, based on observed residues (ATOM records): (download) 
    >1wdwC (C:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslyeipktaydllrrak
ricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkkkveellg
i

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwD (D:)
mwfgefggqyvpetlieplkelekaykrfkddeefnrqlnyylktwagrptplyyakrlt
ekiggakiylkredlvhggahktnnaigqallakfmgktrliaetgagqhgvatamagal
lgmkvdiymgaedverqkmnvfrmkllganvipvnsgsrtlkdainealrdwvatfeyth
yligsvvgphpyptivrdfqsvigreakaqileaegqlpdvivacvgggsnamgifypfv
ndkkvklvgveaggkglesgkhsaslnagqvgvfhgmlsyflqdeegqikpthsiapgld
ypgvgpehaylkkiqraeyvtvtdeealkafhelsrtegiipalesahavayamklakem
srdeiiivnlsgrgdkdldivlkvs

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwE (E:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygttgareeipktay
dllrrakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkk
kveellgi

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwF (F:)
mwfgefggqyvpetlieplkelekaykrfkddeefnrqlnyylktwagrptplyyakrlt
ekiggakiylkredlvhggahktnnaigqallakfmgktrliaetgagqhgvatamagal
lgmkvdiymgaedverqkmnvfrmkllganvipvnsgsrtlkdainealrdwvatfeyth
yligsvvgphpyptivrdfqsvigreakaqileaegqlpdvivacvgggsnamgifypfv
ndkkvklvgveaggkglesgkhsaslnagqvgvfhgmlsyflqdeegqikpthsiapgld
ypgvgpehaylkkiqraeyvtvtdeealkafhelsrtegiipalesahavayamklakem
srdeiiivnlsgrgdkdldivlkvs

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1wdwG (G:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygttgareeipktay
dllrrakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkk
kveellgi

    Sequence, based on observed residues (ATOM records): (download) 
    >1wdwG (G:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslyeeipktaydllrra
kricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkkkveell
gi

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwH (H:)
mwfgefggqyvpetlieplkelekaykrfkddeefnrqlnyylktwagrptplyyakrlt
ekiggakiylkredlvhggahktnnaigqallakfmgktrliaetgagqhgvatamagal
lgmkvdiymgaedverqkmnvfrmkllganvipvnsgsrtlkdainealrdwvatfeyth
yligsvvgphpyptivrdfqsvigreakaqileaegqlpdvivacvgggsnamgifypfv
ndkkvklvgveaggkglesgkhsaslnagqvgvfhgmlsyflqdeegqikpthsiapgld
ypgvgpehaylkkiqraeyvtvtdeealkafhelsrtegiipalesahavayamklakem
srdeiiivnlsgrgdkdldivlkvs

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1wdwI (I:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygttgareeipktay
dllrrakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkk
kveellgi

    Sequence, based on observed residues (ATOM records): (download) 
    >1wdwI (I:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygreeipktaydllr
rakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkkkvee
llgi

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwJ (J:)
mwfgefggqyvpetlieplkelekaykrfkddeefnrqlnyylktwagrptplyyakrlt
ekiggakiylkredlvhggahktnnaigqallakfmgktrliaetgagqhgvatamagal
lgmkvdiymgaedverqkmnvfrmkllganvipvnsgsrtlkdainealrdwvatfeyth
yligsvvgphpyptivrdfqsvigreakaqileaegqlpdvivacvgggsnamgifypfv
ndkkvklvgveaggkglesgkhsaslnagqvgvfhgmlsyflqdeegqikpthsiapgld
ypgvgpehaylkkiqraeyvtvtdeealkafhelsrtegiipalesahavayamklakem
srdeiiivnlsgrgdkdldivlkvs

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1wdwK (K:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvslygttgareeipktay
dllrrakricrnkvavgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkk
kveellgi

    Sequence, based on observed residues (ATOM records): (download) 
    >1wdwK (K:)
mfkdgslipyltagdpdkqstlnfllaldeyagaielgipfsdpiadgktiqeshyralk
ngfklreafwivkefrrhsstpivlmtyynpiyragvrnflaeakasgvdgilvvdlpvf
hakefteiareegiktvflaapntpderlkviddmttgfvylvsaydllrrakricrnkv
avgfgvskrehvvsllkegangvvvgsalvkiigekgreateflkkkveellgi

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wdwL (L:)
mwfgefggqyvpetlieplkelekaykrfkddeefnrqlnyylktwagrptplyyakrlt
ekiggakiylkredlvhggahktnnaigqallakfmgktrliaetgagqhgvatamagal
lgmkvdiymgaedverqkmnvfrmkllganvipvnsgsrtlkdainealrdwvatfeyth
yligsvvgphpyptivrdfqsvigreakaqileaegqlpdvivacvgggsnamgifypfv
ndkkvklvgveaggkglesgkhsaslnagqvgvfhgmlsyflqdeegqikpthsiapgld
ypgvgpehaylkkiqraeyvtvtdeealkafhelsrtegiipalesahavayamklakem
srdeiiivnlsgrgdkdldivlkvs