PDB entry 1nf7

View 1nf7 on RCSB PDB site
Description: Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide
Class: oxidoreductase
Keywords: 8 stranded paralle alpha/beta barrel, dehydrogenase, impd, impdh, ribavirin monophosphate, c2-mad, oxidoreductase
Deposited on 2002-12-13, released 2004-01-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: 0.238
AEROSPACI score: -1.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Inosine-5'-monophosphate dehydrogenase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: IMPDH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1nf7a1, d1nf7a4
  • Chain 'B':
    Compound: Inosine-5'-monophosphate dehydrogenase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: IMPDH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1nf7b1, d1nf7b4
  • Heterogens: K, RVP, MYD, UNK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1nf7A (A:)
madylisggtsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkit
lktplvsspmdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeqgfitdpvv
lspkdrvrdvfeakarhgfcgipitdtgrmgsrlvgiissrdidflkeeehdcfleeimt
kredlvvapagitlkeaneilqrskkgklpivneddelvaiiartdlkknrdyplaskda
kkqllcgaaigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqvi
ggnvvtaaqaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvp
viadggiqnvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldam
dkhlssqnryfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvr
ammysgelkfekrtssaqveggvhslhsyekrlf

    Sequence, based on observed residues (ATOM records): (download) 
    >1nf7A (A:)
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeqgfitdpvvlspkgiiss
rdidflehdcfleeimtkredlvvapagitlkeaneilqrskkgklpivneddelvaiia
rtlkknrdyplaskdakkqllcgaaigtheddkyrldllaqagvdvvvldssqgnsifqi
nmikyikdkypnlqviggnvvtaaqaknlidagvdalrvgmgsgsicitqevlacgrpqa
tavykvseyarrfgvpviadggiqnvghiakalalgastvmmgsllaatteapgeyffsd
girlkkyrgmgsldamikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvr
ammysgelkfekrtssaqveggvhslhsyekrlf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1nf7B (B:)
madylisggtsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkit
lktplvsspmdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeqgfitdpvv
lspkdrvrdvfeakarhgfcgipitdtgrmgsrlvgiissrdidflkeeehdcfleeimt
kredlvvapagitlkeaneilqrskkgklpivneddelvaiiartdlkknrdyplaskda
kkqllcgaaigtheddkyrldllaqagvdvvvldssqgnsifqinmikyikdkypnlqvi
ggnvvtaaqaknlidagvdalrvgmgsgsicitqevlacgrpqatavykvseyarrfgvp
viadggiqnvghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldam
dkhlssqnryfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvr
ammysgelkfekrtssaqveggvhslhsyekrlf

    Sequence, based on observed residues (ATOM records): (download) 
    >1nf7B (B:)
tsyvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvssp
mdtvteagmaiamaltggigfihhnctpefqanevrkvkkyeqgfitdpvvlspkgiiss
rdidflehdcfleeimtkredlvvapagitlkeaneilqrskkgklpivneddelvaiia
rtlkknrdyplaskdakkqllcgaaigtheddkyrldllaqagvdvvvldssqgnsifqi
nmikyikdkypnlqviggnvvtaaqaknlidagvdalrvgmgsgsicitqevlacgrpqa
tavykvseyarrfgvpviadggiqnvghiakalalgastvmmgsllaatteapgeyffsd
girlkkyrgmgsldamikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvr
ammysgelkfekrtssaqveggvhslhsyekrlf