PDB entry 1hcq

View 1hcq on RCSB PDB site
Description: the crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements
Class: transcription/DNA
Keywords: protein-DNA complex, complexed with drug, transcription/DNA complex
Deposited on 1995-01-04, released 1995-11-23
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.204
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (estrogen receptor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • initial methionine (0)
    Domains in SCOPe 2.04: d1hcqa_
  • Chain 'B':
    Compound: protein (estrogen receptor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1hcqb_
  • Chain 'C':
    Compound: DNA (5'-d(*cp*cp*ap*gp*gp*tp*cp*ap*cp*ap*gp*tp*gp*ap*cp*cp*t p*g)-3')
  • Chain 'D':
    Compound: DNA (5'-d(*cp*cp*ap*gp*gp*tp*cp*ap*cp*tp*gp*tp*gp*ap*cp*cp*t p*g)-3')
  • Chain 'E':
    Compound: protein (estrogen receptor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (1-End)
      • initial methionine (0)
    Domains in SCOPe 2.04: d1hcqe_
  • Chain 'F':
    Compound: protein (estrogen receptor)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d1hcqf_
  • Chain 'G':
    Compound: DNA (5'-d(*cp*cp*ap*gp*gp*tp*cp*ap*cp*ap*gp*tp*gp*ap*cp*cp*t p*g)-3')
  • Chain 'H':
    Compound: DNA (5'-d(*cp*cp*ap*gp*gp*tp*cp*ap*cp*tp*gp*tp*gp*ap*cp*cp*t p*g)-3')
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1hcqA (A:)
mketrycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscq
acrlrkcyevgmmkggirkdrrgg

    Sequence, based on observed residues (ATOM records): (download) 
    >1hcqA (A:)
mketrycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscq
acrlrkcyevgmmk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1hcqB (B:)
mketrycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscq
acrlrkcyevgmmkggirkdrrgg

    Sequence, based on observed residues (ATOM records): (download) 
    >1hcqB (B:)
trycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscqacr
lrkcyevgmmk

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1hcqE (E:)
mketrycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscq
acrlrkcyevgmmkggirkdrrgg

    Sequence, based on observed residues (ATOM records): (download) 
    >1hcqE (E:)
mketrycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscq
acrlrkcyevgmmk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1hcqF (F:)
mketrycavcndyasgyhygvwscegckaffkrsiqghndymcpatnqctidknrrkscq
acrlrkcyevgmmkggirkdrrgg

    Sequence, based on observed residues (ATOM records): (download) 
    >1hcqF (F:)
ketrycavcndyasgyhygvwscegckaffkrsiqgdymcpatnqctidknrrkscqacr
lrkcyevgmmk

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.