SCOPe 2.08: Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module

Lineage for Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (8 proteins)
   the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology

Proteins:

1. Acetohydroxyacid synthase catalytic subunit [88758] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88759] (8 PDB entries)
      Uniprot P07342 84-687

   2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [314110] (3 PDB entries)

   3. Species Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142208] (12 PDB entries)
      Uniprot P17597 460-667

2. Benzoylformate decarboxylase [88756] (1 species)

   • Species Pseudomonas putida [TaxId:303] [88757] (7 PDB entries)
     Uniprot P20906

3. Carboxyethylarginine synthase [102335] (1 species)

   • Species Streptomyces clavuligerus [TaxId:1901] [102336] (6 PDB entries)

4. Catabolic acetolactate synthase [102333] (1 species)

   • Species Klebsiella pneumoniae [TaxId:573] [102334] (3 PDB entries)

5. Indole-3-pyruvate decarboxylase [89654] (1 species)

   • Species Enterobacter cloacae [TaxId:550] [89655] (1 PDB entry)

6. Oxalyl-CoA decarboxylase [142209] (1 species)

   • Species Oxalobacter formigenes [TaxId:847] [142210] (6 PDB entries)
     Uniprot P40149 370-552

7. Pyruvate decarboxylase [88750] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88752] (2 PDB entries)

   2. Species Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [88751] (1 PDB entry)

   3. Species Zymomonas mobilis [TaxId:542] [88753] (1 PDB entry)

8. Pyruvate oxidase [88754] (2 species)

   1. Species Aerococcus viridans [TaxId:1377] [142207] (2 PDB entries)

   2. Species Lactobacillus plantarum [TaxId:1590] [88755] (2 PDB entries)

More info for Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module

Timeline for Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module:

• Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module first appeared in SCOP 1.65
  
• Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module appears in SCOPe 2.07