SCOPe 2.03: Domain d1n46a_: 1n46 A:

Lineage for d1n46a_ (1n46 A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Thyroid hormone receptor beta (TR-beta) [48530] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48531] (14 PDB entries)
   Uniprot P10828 202-460

8. Domain d1n46a_: 1n46 A: [85315]
   complexed with pfa

Details for d1n46a_

PDB Entry: 1n46, 2.2 Å

PDB Description: crystal structure of human tr beta ligand-binding domain complexed with a potent subtype-selective thyromimetic

PDB Compounds: (A:) Thyroid hormone receptor Beta-1

SCOPe Domain Sequences for d1n46a_:

Sequence, based on SEQRES records:

>d1n46a_ a.123.1.1 (A:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
kpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivnapeggkvdleafs
hftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltl
ngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacve
riekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptel
fpplflevfed

Sequence, based on observed residues (ATOM records):

>d1n46a_ a.123.1.1 (A:) Thyroid hormone receptor beta (TR-beta) {Human (Homo sapiens) [TaxId: 9606]}
kpeptdeeweliktvteahvatnaqwkqkrkflpedigqapivnapeggkvdleafshft
kiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltlnge
mavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacverie
kyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelfpp
lflevfed

Timeline for d1n46a_:

• d1n46a_ first appeared in SCOP 1.65
  
• d1n46a_ appears in SCOPe 2.02
  
• d1n46a_ appears in SCOPe 2.04
  
• d1n46a_ appears in the current release, SCOPe 2.08