SCOP 1.67: Domain d1mdwb_: 1mdw B:

Lineage for d1mdwb_ (1mdw B:)

1. Root: SCOP 1.67

2. Class d: Alpha and beta proteins (a+b) [53931] (260 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (10 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)

6. Protein Calpain large subunit, catalytic domain (domain II) [54041] (3 species)
   includes the N-terminal 'sequence' domain I

7. Species Rat (Rattus norvegicus), M-type [TaxId:10116] [54043] (2 PDB entries)

8. Domain d1mdwb_: 1mdw B: [84935]
   calcium-bound protease core
   complexed with ca; mutant

Details for d1mdwb_

PDB Entry: 1mdw, 1.95 Å

PDB Description: crystal structure of calcium-bound protease core of calpain ii reveals the basis for intrinsic inactivation

SCOP Domain Sequences for d1mdwb_:

Sequence, based on SEQRES records:

>d1mdwb_ d.3.1.3 (B:) Calpain large subunit, catalytic domain (domain II) {Rat (Rattus norvegicus), M-type}
raikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrpteic
adpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagifhfq
fwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsggatte
gfedftggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqklvkgh
aysvtgaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlterqedg
efwmsfsdflrhysrleicnltp

Sequence, based on observed residues (ATOM records):

>d1mdwb_ d.3.1.3 (B:) Calpain large subunit, catalytic domain (domain II) {Rat (Rattus norvegicus), M-type}
raikylnqdyetlrnecleagalfqdpsfpalpsslgfkelgpyssktrgiewkrpteic
adpqfiiggatrtdicqgalgdswllaaiasltlneeilarvvpldqsfqenyagifhfq
fwqygewvevvvddrlptkdgellfvhsaegsefwsallekayakingcyealsegfedf
tggiaewyelrkpppnlfkiiqkalekgsllgcsiditsaadseavtyqklvkghaysvt
gaeevessgslqklirirnpwgqvewtgkwndncpswntvdpevranlterqedgefwms
fsdflrhysrleicnltp

Timeline for d1mdwb_:

• d1mdwb_ first appeared in SCOP 1.65
  
• d1mdwb_ appears in SCOP 1.69
  
• d1mdwb_ appears in the current release, SCOPe 2.08